Structure-activity Studies on a Novel Series of Cholinergic Channel Activators Based on a Heteroaryl Ether Framework

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 1999 Oct 6

PMID 10509928

Citations 1

Authors

N H Lin

M A Abreo

D E Gunn

S A Lebold

E L Lee

J T Wasicak

A M Hettinger

J F Daanen

D S Garvey

J E Campbell

J P Sullivan

M Williams

S P Arneric

Affiliations

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Abstract

Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited Ki values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).

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