S M Crain
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Explore the profile of S M Crain including associated specialties, affiliations and a list of published articles.
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141
Citations
1262
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Recent Articles
1.
Model P, Bornstein M, Crain S, Pappas G
J Cell Biol
. 2009 Oct;
49(2):362-71.
PMID: 19866764
Explants of fetal mouse cerebral cortex, continuously exposed to the local anesthetic Xylocaine from the time of explantation to the time of fixation, were examined in the electron microscope to...
2.
Shen K, Crain S
Brain Res
. 2001 Nov;
919(1):20-30.
PMID: 11689159
In a previous study we demonstrated that injection (i.p.) of low doses of GM1 ganglioside in mice rapidly attenuates morphine's analgesic effects. This result is consonant with our electrophysiologic studies...
3.
Crain S, Shen K
Brain Res
. 2001 Jan;
888(1):75-82.
PMID: 11146054
Our previous electrophysiologic studies on nociceptive types of dorsal root ganglion (DRG) neurons in culture demonstrated that extremely low fM-nM concentrations of morphine and many other bimodally-acting mu, delta and...
4.
Crain S, Shen K
Brain Res
. 2000 Mar;
856(1-2):227-35.
PMID: 10677630
10-fold higher doses in SW mice. Furthermore, cotreatment of 129/SvEv mice with morphine plus a low dose of naltrexone (ca. 0.1 microgram/kg) that markedly enhances and prolongs morphine's antinociceptive effects...
5.
Crain S, Shen K
Pain
. 2000 Feb;
84(2-3):121-31.
PMID: 10666516
Recent preclinical and clinical studies have demonstrated that cotreatments with extremely low doses of opioid receptor antagonists can markedly enhance the efficacy and specificity of morphine and related opioid analgesics....
6.
Crain S
Methods
. 1999 Mar;
16(3):228-38.
PMID: 10071063
This article provides a broad overview of the significant roles that morphophysiologic analyses of organotypic cultures of neural tissues explanted in vitro-initiated during the 1950s-have played in stimulating the more...
7.
Crain S, Shen K
Trends Pharmacol Sci
. 1998 Oct;
19(9):358-65.
PMID: 9786023
Studies of direct excitatory effects elicited by opioid agonists on various types of neurone have been confirmed and expanded in numerous laboratories following the initial findings reviewed previously by Stanley...
8.
Crain S, Shen K
Ann N Y Acad Sci
. 1998 Jul;
845:106-25.
PMID: 9668346
Electrophysiologic studies of dorsal-root ganglion (DRG) neurons in culture have demonstrated both excitatory (Gs-coupled) as well as inhibitory (Gi/Go-coupled) opioid receptor-mediated actions. Brief treatment of DRG neurons with cholera toxin-beta...
9.
Shen K, Crain S
Brain Res
. 1997 May;
757(2):176-90.
PMID: 9200746
In previous studies we showed that low (pM) concentrations of naloxone (NLX), naltrexone (NTX) or etorphine selectively antagonize excitatory, but not inhibitory, opioid receptor-mediated functions in nociceptive types of sensory...
10.
Fan S, Crain S
Brain Res
. 1997 Apr;
754(1-2):303-6.
PMID: 9134988
Etorphine is an non-selective opioid receptor agonist with very potent analgesic effect. Low concentrations (< nM) of most opioid receptor agonists decrease the K+ conductance (gK) in cultures of dissociated...