S K Duddy
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Explore the profile of S K Duddy including associated specialties, affiliations and a list of published articles.
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20
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274
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Recent Articles
1.
Kiley S, Clark K, Duddy S, Welch D, Jaken S
Oncogene
. 1999 Dec;
18(48):6748-57.
PMID: 10597283
Relatively little is known about the molecular mechanisms of tumor promotion/progression in mammary carcinogenesis. Increased protein kinase C (PKC) activity is known to promote tumor formation in several tissues; however,...
2.
Duddy S, Gorospe S, Bleavins M, de la Iglesia F
Toxicol Appl Pharmacol
. 1999 Oct;
160(2):133-40.
PMID: 10527912
Hemangiosarcomasare uncommon malignant endothelial cell tumors in humans and experimental animal species. The mechanisms giving rise to these tumors are poorly understood even though the histotypes are comparable between humans...
3.
Duddy S, PARKER R, Bleavins M, Gough A, Rowse P, Gorospe S, et al.
Toxicol Appl Pharmacol
. 1999 Apr;
156(2):106-12.
PMID: 10198275
Hemangiomas and hemangiosarcomas are uncommon in rodents and humans and, as such, the mechanisms giving rise to these tumors are poorly understood. Inactivating mutations in the p53 gene have been...
4.
Duddy S, Gorospe S, Bleavins M
Toxicol Sci
. 1999 Feb;
46(2):317-23.
PMID: 10048135
Molecular analysis of alterations in genomic DNA is essential for understanding mechanisms by which chemical agents induce or modify tumor development. The assessment of microsatellite polymorphisms, loss of heterozygosity, mutations,...
5.
Duddy S, Earp H, RUSSELL W, Smith G, Grisham J
Cell Growth Differ
. 1995 Mar;
6(3):251-61.
PMID: 7794793
The tumorigenic phenotype in rat liver epithelial cells overexpressing c-myc may depend on a transforming growth factor (TGF)-alpha/epidermal growth factor receptor autocrine loop (L. W. Lee et al., Cancer Res.,...
6.
Llopis J, Farrell G, Duddy S, Kass G, Gahm A, Orrenius S
Biochem Pharmacol
. 1993 Jun;
45(11):2209-14.
PMID: 8390834
In the isolated perfused rat liver 2,5-di(tert-butyl)hydroquinone (tBuHQ), a selective inhibitor of the endoplasmic reticulum Ca2+ pump, induces a prolonged glucose output and stimulates Ca2+ efflux. The present study shows...
7.
Llopis J, Kass G, Duddy S, Farell G, Gahm A, Orrenius S
FEBS Lett
. 1991 Mar;
280(1):84-6.
PMID: 2009970
Hepatocyte tight junctional permeability has been shown to be regulated by hormones that exert their effects via phospholipase C activation. However, the precise transduction pathway involved in this effect is...
8.
Kass G, Llopis J, Chow S, Duddy S, Orrenius S
J Biol Chem
. 1990 Oct;
265(29):17486-92.
PMID: 2170382
Agonist-stimulated divalent cation entry was studied in fura-2-loaded hepatocytes. In the presence of extracellular Mn2+, the Ca2(+)-mobilizing hormone vasopressin produced a severalfold stimulation of the basal rate of fura-2 fluorescence...
9.
Farrell G, Duddy S, Kass G, Llopis J, Gahm A, Orrenius S
J Clin Invest
. 1990 Apr;
85(4):1255-9.
PMID: 2318979
The hypothesis that monohydroxy bile acids exert their cholestatic and hepatotoxic effects via a sustained elevation of cytosolic [Ca2+] was tested in the isolated perfused rat liver. Infusion of the...
10.
Moore G, Kass G, Duddy S, Farrell G, Llopis J, Orrenius S
Free Radic Res Commun
. 1990 Jan;
8(4-6):337-45.
PMID: 2354809
Isolated hepatocytes and the isolated perfused rat liver have been used to study the alterations of cytosolic free Ca2+ concentration ([Ca2+]i) produced by 2,5-di(tert-butyl)-1,4-benzohydroquinone (tBuBHQ), a potent inhibitor of hepatic...