S J Engle
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Explore the profile of S J Engle including associated specialties, affiliations and a list of published articles.
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14
Citations
491
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Recent Articles
1.
Schultz J, Witt S, Nieman M, Reiser P, Engle S, Zhou M, et al.
J Clin Invest
. 1999 Sep;
104(6):709-19.
PMID: 10491406
In vitro, fibroblast growth factor-2 (FGF2) has been implicated in cardiomyocyte growth and reexpression of fetal contractile genes, both markers of hypertrophy. However, its in vivo role in cardiac hypertrophy...
2.
Engle S, Hoying J, Boivin G, Ormsby I, Gartside P, Doetschman T
Cancer Res
. 1999 Jul;
59(14):3379-86.
PMID: 10416598
The transforming growth factor beta (TGF-beta) pathway is known to play an important role in both human and urine colon cancer. However, the staging, ligand specificity, and mechanism underlying the...
3.
Horseman N, Zhao W, Tanaka M, Nakashima K, Engle S, Smith F, et al.
EMBO J
. 1998 Jan;
16(23):6926-35.
PMID: 9384572
Prolactin (PRL) has been implicated in numerous physiological and developmental processes. The mouse PRL gene was disrupted by homologous recombination. The mutation caused infertility in female mice, but did not...
4.
Horseman N, Engle S, Ralescu A
Trends Endocrinol Metab
. 1997 May;
8(4):123-9.
PMID: 18406797
The apparent imprecisions in the signal transduction mechanisms that couple specific hormone receptors to predictable nuclear transcription events have raised many issues for both biology and medicine. In this article,...
5.
Tian M, Broxmeyer H, Fan Y, Lai Z, Zhang S, Aronica S, et al.
J Exp Med
. 1997 Apr;
185(8):1517-22.
PMID: 9126934
The mu opioid receptor is thought to be the cellular target of opioid narcotics such as morphine and heroin, mediating their effects in both pain relief and euphoria. Its involvement...
6.
Engle S, Womer D, Davies P, Boivin G, Sahota A, Simmonds H, et al.
Hum Mol Genet
. 1996 Oct;
5(10):1607-10.
PMID: 8894695
Complete hypoxanthine-guanine phosphoribosyl-transferase (HPRT) deficiency in humans results in the Lesch-Nyhan syndrome which is characterized, among other features, by compulsive self-injurious behavior. HPRT-deficient mice generated using mouse embryonic stem cells...
7.
Engle S, Stockelman M, Chen J, Boivin G, Yum M, Davies P, et al.
Proc Natl Acad Sci U S A
. 1996 May;
93(11):5307-12.
PMID: 8643571
Adenine phosphoribosyltransferase (APRT) deficiency in humans is an autosomal recessive syndrome characterized by the urinary excretion of adenine and the highly insoluble compound 2,8-dihydroxyadenine (DHA) that can produce kidney stones...
8.
Tischfield J, Xia Y, Shih D, Klisak I, Chen J, Engle S, et al.
Genomics
. 1996 Mar;
32(3):328-33.
PMID: 8838795
The Group IIA phospholipase gene (PLA2G2A) protein coding regions exhibit significant homology with recently described Group IIC (PLA2G2C) and Group V (PLA2GV) genes. All three genes are present in many...
9.
Stambrook P, Shao C, Stockelman M, Boivin G, Engle S, Tischfield J
Environ Mol Mutagen
. 1996 Jan;
28(4):471-82.
PMID: 8991080
We describe an in vivo mutagenesis model that utilizes reverse mutation and forward mutation at the endogenous Aprt locus. Reverse mutation provides an in situ method for detecting environments or...
10.
Chen J, Engle S, Seilhamer J, Tischfield J
Biochim Biophys Acta
. 1994 Nov;
1215(1-2):115-20.
PMID: 7947992
We report the cloning of a novel rat cDNA encoding a Ca(2+)-dependent, low molecular weight phospholipase A2 (PLA2). A rat RNA blot hybridized with the cDNA exhibited a putative 2.4...