S J Edelstein
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Explore the profile of S J Edelstein including associated specialties, affiliations and a list of published articles.
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99
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1022
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Recent Articles
1.
Palanche T, Ilien B, Zoffmann S, Reck M, Bucher B, Edelstein S, et al.
J Biol Chem
. 2001 Jul;
276(37):34853-61.
PMID: 11459843
G protein-coupled receptors are thought to mediate agonist-evoked signal transduction by interconverting between discrete conformational states endowed with different pharmacological and functional properties. In order to address the question of...
2.
Changeux J, Edelstein S
Curr Opin Neurobiol
. 2001 Jun;
11(3):369-77.
PMID: 11399437
Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect...
3.
Bohler S, Gay S, Bertrand S, Corringer P, Edelstein S, Changeux J, et al.
Biochemistry
. 2001 May;
40(7):2066-74.
PMID: 11329274
Desensitization is a general property of ligand-gated ion channels. Because of a wide array of available subunit combinations, it generates different time constants for channel closure, thereby modulating the processing...
4.
Martinez K, Corringer P, Edelstein S, Changeux J, Merola F
Biochemistry
. 2000 Jun;
39(23):6979-90.
PMID: 10841780
The nicotinic acetylcholine receptor (nAChR) from Torpedo marmorata carries two nonequivalent agonist binding sites at the alphadelta and alphagamma subunit interfaces. These sites have been characterized by time-resolved fluorescence with...
5.
Marden M, Kiger L, Poyart C, Edelstein S
Cell Mol Life Sci
. 1999 Jan;
54(12):1365-84.
PMID: 9893711
While most researchers agree on the global features of cooperative ligand binding to haemoglobin (Hb), the internal mechanisms remain open to debate. This is not due to inaccurate measurements, but...
6.
7.
Edelstein S, Changeux J
Adv Protein Chem
. 1998 Jun;
51:121-84.
PMID: 9615170
No abstract available.
8.
Kiger L, Dumoulin A, Edelstein S, Abraham D, Prome D, Poyart C, et al.
Biochemistry
. 1998 Jun;
37(20):7328-39.
PMID: 9585547
Among the numerous strategies to design an oxygen carrier, we outline in this work the engineering of a stable homotetrameric hemoglobin, expressed in Escherichia coli. The chimeric globin (Psi) consists...
9.
Edelstein S, Schaad O, Changeux J
C R Acad Sci III
. 1998 May;
320(12):953-61.
PMID: 9587473
An extended Monod-Wyman-Changeux allosteric-type model is applied to human muscle nicotinic acetylcholine receptors expressed in HEK cells, for both the normal form and the high-affinity human myasthenic mutant, epsilon T264P....
10.
Corringer P, Bertrand S, Bohler S, Edelstein S, Changeux J, Bertrand D
J Neurosci
. 1998 Feb;
18(2):648-57.
PMID: 9425007
To identify the molecular determinants underlying the pharmacological diversity of neuronal nicotinic acetylcholine receptors, we compared the alpha7 homo-oligomeric and alpha4beta2 hetero-oligomeric receptors. Sets of residues from the regions initially...