Ryotaro Saiki
Overview
Explore the profile of Ryotaro Saiki including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
268
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Recent Articles
11.
Mizoi M, Yoshida M, Saiki R, Waragai M, Uemura K, Akatsu H, et al.
Clin Chim Acta
. 2014 Feb;
430:150-5.
PMID: 24508996
Background: We found previously that the amyloid β40/42 (Aβ40/42) ratio and the level of protein-conjugated acrolein (PC-Acro) in plasma were increased in mild cognitive impairment (MCI) and Alzheimer's disease (AD)...
12.
Saiki R, Hayashi D, Ikuo Y, Nishimura K, Ishii I, Kobayashi K, et al.
J Neurochem
. 2013 Jun;
127(5):652-9.
PMID: 23763486
Measurements of protein-conjugated acrolein (PC-Acro), IL-6, and C-reactive protein (CRP) in plasma were useful for identifying silent brain infarction with high sensitivity and specificity. The aim of this study was...
13.
Saiki R, Yoshizawa Y, Minarini A, Milelli A, Marchetti C, Tumiatti V, et al.
Bioorg Med Chem Lett
. 2013 May;
23(13):3901-4.
PMID: 23692871
The biological activities of six symmetrically substituted 2-methoxy-benzyl polymethylene tetraamines (1-4) and diphenylethyl polymethylene tetraamines (5 and 6) as N-methyl-D-aspartate (NMDA) receptor channel blockers, were evaluated in vitro and in...
14.
Yamashita T, Nishimura K, Saiki R, Okudaira H, Tome M, Higashi K, et al.
Int J Biochem Cell Biol
. 2013 Mar;
45(6):1042-50.
PMID: 23500523
The role of polyamines at the G1/S boundary and in the G2/M phase of the cell cycle was studied using synchronized HeLa cells treated with thymidine or with thymidine and...
15.
Watanabe K, Nakazato Y, Saiki R, Igarashi K, Kitada M, Ishii I
Atherosclerosis
. 2013 Jan;
227(1):51-7.
PMID: 23305793
Objective: Acrolein-conjugated lysine residues in proteins are present in human atherosclerotic lesions, and are detected in human low-density lipoprotein (LDL). These findings suggest that acrolein may contribute to macrophage foam...
16.
Nakamura M, Tomitori H, Suzuki T, Sakamoto A, Terui Y, Saiki R, et al.
Biochem Biophys Res Commun
. 2012 Dec;
430(4):1265-71.
PMID: 23261472
We have recently reported that acrolein is more toxic than reactive oxygen species. Thus, the mechanism of cell toxicity by acrolein was studied using mouse mammary carcinoma FM3A cells. Acrolein-conjugated...
17.
Waragai M, Yoshida M, Mizoi M, Saiki R, Kashiwagi K, Takagi K, et al.
J Alzheimers Dis
. 2012 Jul;
32(1):33-41.
PMID: 22751175
The objective of this study was to determine whether plasma levels of acrolein, a compound that causes cell damage, and amyloid-β (Aβ) are useful biochemical markers for Alzheimer's disease (AD)....
18.
Tomitori H, Suganami A, Saiki R, Mizuno S, Yoshizawa Y, Masuko T, et al.
J Pharmacol Exp Ther
. 2012 Jun;
343(1):82-90.
PMID: 22743575
Modeling the binding sites for spermine and ifenprodil on the regulatory (R) domains of the N-methyl-D-aspartate receptor GluN1 and GluN2B subunits was carried out after measuring spermine stimulation and ifenprodil...
19.
Zhang D, Zhao T, Ang H, Chong P, Saiki R, Igarashi K, et al.
Genes Dev
. 2012 Mar;
26(5):461-73.
PMID: 22391449
The gene expression networks governing embryonic stem cell (ESC) pluripotency are complex and finely regulated during differentiation toward specific lineages. We describe a new role for Amd1 (adenosyl methionine decarboxylase),...
20.
Yoshida M, Mikami T, Higashi K, Saiki R, Mizoi M, Fukuda K, et al.
Clin Chim Acta
. 2012 Feb;
413(7-8):753-9.
PMID: 22293277
Background: We found previously that increases in plasma levels of protein-conjugated acrolein and polyamine oxidases, enzymes that produce acrolein, are good biomarkers for stroke. The aim of this study was...