Kazuei Igarashi
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Explore the profile of Kazuei Igarashi including associated specialties, affiliations and a list of published articles.
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Articles
188
Citations
3059
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Recent Articles
1.
Kobayashi T, Sakamoto A, Hisano T, Kashiwagi K, Igarashi K, Takao K, et al.
Sci Rep
. 2024 Mar;
14(1):7566.
PMID: 38555406
An extreme thermophilic bacterium, Thermus thermophilus produces more than 20 unusual polyamines, but their biosynthetic pathways, including homospermidine, are not yet fully understood. Two types of homospermidine synthases have been...
2.
Miyajima R, Manaka H, Honda T, Hashii N, Suzuki M, Komeno M, et al.
J Biotechnol
. 2023 Nov;
378:1-10.
PMID: 37922995
The heterogeneity of the N-linked glycan profile of therapeutic monoclonal antibodies (mAbs) derived from animal cells affects therapeutic efficacy and, therefore, needs to be appropriately controlled during the manufacturing process....
3.
Sakamoto A, Terui Y, Igarashi K, Kashiwagi K
Int J Mol Sci
. 2023 Jul;
24(14).
PMID: 37511605
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective ion channel implicated in thermosensation and inflammatory pain. It has been reported that expression of the TRPA1 channel is induced by...
4.
Sanayama H, Ito K, Ookawara S, Uemura T, Sakiyama Y, Sugawara H, et al.
Biomedicines
. 2023 May;
11(5).
PMID: 37239074
Early diagnosis and therapeutic intervention improve the quality of life and prognosis of patients with sarcopenia. The natural polyamines spermine and spermidine are involved in many physiological activities. Therefore, we...
5.
Kobayashi T, Sakamoto A, Kashiwagi K, Igarashi K, Takao K, Uemura T, et al.
J Biochem
. 2023 Mar;
174(1):81-88.
PMID: 37001547
In the three domains of life, three biosynthetic pathways are known for putrescine. The first route is conversion of ornithine to putrescine by ornithine decarboxylase (ODC: SpeC), the second route...
6.
Sanayama H, Ito K, Ookawara S, Uemura T, Imai S, Kiryu S, et al.
Biomedicines
. 2023 Mar;
11(3).
PMID: 36979725
Several mechanisms strictly regulate polyamine concentration, and blood polyamines are excreted in urine. This indicates polyamine accumulation in renal dysfunction, and studies have shown increased blood polyamine concentrations in patients...
7.
Kashiwagi K, Igarashi K
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830667
Acrolein (CH=CH-CHO), an unsaturated aldehyde produced from spermine, is one of the major contributors to oxidative stress. Acrolein has been found to be more toxic than reactive oxygen species (HO...
8.
Uemura T, Uchida M, Nakamura M, Shimekake M, Sakamoto A, Terui Y, et al.
Amino Acids
. 2023 Feb;
55(4):509-518.
PMID: 36752871
Brain stroke is a major cause of being bedridden for elderly people, and preventing stroke is important for maintaining quality of life (QOL). Acrolein is a highly reactive aldehyde and...
9.
Yoshida M, Uemura T, Mizoi M, Waragai M, Sakamoto A, Terui Y, et al.
J Alzheimers Dis
. 2023 Feb;
92(1):361-369.
PMID: 36744340
Background: Dementia, including Alzheimer's disease (AD), is one of the serious diseases at advanced age, and its early detection is important for maintaining quality of life (QOL). Objective: In this...
10.
Kobayashi T, Sakamoto A, Kashiwagi K, Igarashi K, Moriya T, Oshima T, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362306
An extreme thermophile, , produces 16 different polyamines including long-chain and branched-chain polyamines. The composition and content of polyamines in the thermophile cells change not only with growth temperature but...