Ryohichi Sugimura
Overview
Explore the profile of Ryohichi Sugimura including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
919
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Recent Articles
1.
Lee S, Wu Z, Huang M, Liang C, Huang Z, Chen S, et al.
Mater Today Bio
. 2025 Feb;
31:101451.
PMID: 39896283
Recently, injectable hydrogels have garnered significant attention in tissue engineering due to their controlled flowability, strong plasticity, adaptability, and good biocompatibility. However, research on readily injectable -forming hydrogels capable of...
2.
To A, Yu Z, Sugimura R
Semin Cell Dev Biol
. 2024 Dec;
166():22-28.
PMID: 39705969
Recent advancements in spatial transcriptomics and spatial proteomics enabled the high-throughput profiling of single or multi-cell types and cell states with spatial information. They transformed our understanding of the higher-order...
3.
Tang W, Sugimura R
Prog Mol Biol Transl Sci
. 2024 Oct;
209:61-100.
PMID: 39461755
Chimeric antigen receptors (CAR) are synthetic receptors engineered to target a user-defined antigen. They comprise an extracellular single-chain variable fragment for target recognition and intracellular signalling domains commonly derived from...
4.
Lin X, Liu Z, Dong X, Wang K, Sun Y, Zhang H, et al.
J Transl Med
. 2024 Oct;
22(1):929.
PMID: 39396988
Background: Chimeric antigen receptor (CAR)-NK cell therapy has shown remarkable clinical efficacy and safety in the treatment of hematological malignancies. However, this efficacy was limited in solid tumors owing to...
5.
Chen H, Bao Y, Li X, Chen F, Sugimura R, Zeng X, et al.
Angew Chem Int Ed Engl
. 2024 Aug;
63(44):e202410566.
PMID: 39103291
Cell therapies such as CAR-T have demonstrated significant clinical successes, driving the investigation of immune cell surface engineering using natural and synthetic materials to enhance their therapeutic performance. However, many...
6.
Feng X, Wu Z, Cheng L, Xiang Y, Sugimura R, Lin X, et al.
Lab Chip
. 2024 Jul;
24(14):3546-3555.
PMID: 38949063
Microfluidic chips have emerged as significant tools in cell culture due to their capacity for supporting cells to adopt more physiologically relevant morphologies in 3D compared with traditional cell culture...
7.
Chau C, To A, Au-Yeung R, Tang K, Xiang Y, Ruan D, et al.
Sci Rep
. 2024 Apr;
14(1):8781.
PMID: 38627497
SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids...
8.
Wan X, Xiao J, Tam S, Cai M, Sugimura R, Wang Y, et al.
Nat Commun
. 2023 Nov;
14(1):7848.
PMID: 38030617
The rapid emergence of spatial transcriptomics (ST) technologies is revolutionizing our understanding of tissue spatial architecture and biology. Although current ST methods, whether based on next-generation sequencing (seq-based approaches) or...
9.
Cao H, Xiang Y, Zhang S, Chao Y, Guo J, Aurich T, et al.
Life Sci Alliance
. 2023 Nov;
7(2).
PMID: 37949473
Programmed death ligand 1 (PD-L1) serves as a pivotal immune checkpoint in both the innate and adaptive immune systems. PD-L1 is expressed in macrophages in response to IFNγ. We examined...
10.
Chan C, Sugimura R
J Leukoc Biol
. 2023 Nov;
115(1):16-18.
PMID: 37934864
This commentary investigates the findings presented in the article by Yang et al. in 2023, published in the Journal of Leukocyte Biology. This commentary first summarizes the spatial-temporal dynamics of...