Ryan Mahling
Overview
Explore the profile of Ryan Mahling including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
12
Citations
155
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Chakouri N, Rivas S, Roybal D, Yang L, Diaz J, Hsu A, et al.
Nat Cardiovasc Res
. 2022 Jun;
1(5):1-13.
PMID: 35662881
Voltage-gated sodium (Nav1.5) channels support the genesis and brisk spatial propagation of action potentials in the heart. Disruption of Na1.5 inactivation results in a small persistent Na influx known as...
2.
Mahling R, Ben-Johny M
Proc Natl Acad Sci U S A
. 2022 Mar;
119(15):e2202254119.
PMID: 35353604
No abstract available.
3.
Mahling R, Hovey L, Isbell H, Marx D, Miller M, Kilpatrick A, et al.
Structure
. 2021 Mar;
29(12):1339-1356.e7.
PMID: 33770503
Neuronal voltage-gated sodium channel Na1.2 C-terminal domain (CTD) binds calmodulin (CaM) constitutively at its IQ motif. A solution structure (6BUT) and other NMR evidence showed that the CaM N domain...
4.
Mahling R, Rahlf C, Hansen S, Hayden M, Shea M
J Biol Chem
. 2021 Feb;
296:100458.
PMID: 33639159
Voltage-gated sodium channels (Nas) are tightly regulated by multiple conserved auxiliary proteins, including the four fibroblast growth factor homologous factors (FGFs), which bind the Na EF-hand like domain (EFL), and...
5.
Isbell H, Kilpatrick A, Lin Z, Mahling R, Shea M
Biomol NMR Assign
. 2018 May;
12(2):283-289.
PMID: 29728980
Human voltage-gated sodium (Na) channels are critical for initiating and propagating action potentials in excitable cells. Nine isoforms have different roles but similar topologies, with a pore-forming α-subunit and auxiliary...
6.
Mahling R, Kilpatrick A, Shea M
Biomol NMR Assign
. 2017 Aug;
11(2):297-303.
PMID: 28823028
Human voltage-gated sodium channel Na1.2 has a single pore-forming α-subunit and two transmembrane β-subunits. Expressed primarily in the brain, Na1.2 is critical for initiation and propagation of action potentials. Milliseconds...
7.
Kruth K, Fang M, Shelton D, Abu-Halawa O, Mahling R, Yang H, et al.
Blood
. 2017 Apr;
129(22):3000-3008.
PMID: 28424165
Glucocorticoids (GCs), including dexamethasone (dex), are a central component of combination chemotherapy for childhood B-cell precursor acute lymphoblastic leukemia (B-ALL). GCs work by activating the GC receptor (GR), a ligand-induced...
8.
Hovey L, Fowler C, Mahling R, Lin Z, Miller M, Marx D, et al.
Biophys Chem
. 2017 Mar;
224:1-19.
PMID: 28343066
Several members of the voltage-gated sodium channel family are regulated by calmodulin (CaM) and ionic calcium. The neuronal voltage-gated sodium channel Na1.2 contains binding sites for both apo (calcium-depleted) and...
9.
Lewis A, Dunleavy K, Senkow T, Her C, Horn B, Jersett M, et al.
Nat Chem Biol
. 2016 Aug;
12(10):860-6.
PMID: 27547920
Oxidation of methionine disrupts the structure and function of a range of proteins, but little is understood about the chemistry that underlies these perturbations. Using quantum mechanical calculations, we found...
10.
Fealey M, Mahling R, Rice A, Dunleavy K, Kobany S, Lohese K, et al.
Biochemistry
. 2016 May;
55(21):2914-26.
PMID: 27191789
Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the calcium ion (Ca(2+)) influx to trigger fast synchronous release of neurotransmitter. How the cytosolic domains of Syt...