Ryan Doonan
Overview
Explore the profile of Ryan Doonan including associated specialties, affiliations and a list of published articles.
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10
Citations
577
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Recent Articles
1.
McDonald K, Larkin K, Dickinson D, Golden A, Bai X, Doonan R
MicroPubl Biol
. 2023 Sep;
2023.
PMID: 37746064
L-type voltage-gated calcium channels (VGCCs) regulate calcium influx and excitation-contraction coupling in many types of muscle cells. Thus, VGCC mutations can cause skeletal and cardiac muscle diseases in humans, such...
2.
Witten G, DeMott E, Huang G, Zelasko F, de Jesus B, Mulchand C, et al.
MicroPubl Biol
. 2023 Jul;
2023.
PMID: 37396790
Fluorescent proteins allow the expression of a gene and the behavior of its protein product to be observed in living animals. The ability to create endogenous fluorescent protein tags via...
3.
DeMott E, Dickinson D, Doonan R
MicroPubl Biol
. 2021 Nov;
2021.
PMID: 34816097
Plasmid-based CRISPR knock-in is a streamlined, scalable, and versatile approach for generating fluorescent protein tags in (Dickinson . 2015; Schwartz and Jorgensen 2016). However, compared to more recent protocols that...
4.
Huang G, de Jesus B, Koh A, Blanco S, Rettmann A, DeMott E, et al.
MicroPubl Biol
. 2021 Sep;
2021.
PMID: 34549176
Streamlined, selection-based CRISPR knock-in protocols for were first introduced six years ago (Dickinson . 2015; Schwartz and Jorgensen 2016). Though these selection-based approaches are powerful, one drawback has been the...
5.
Ashley G, Duong T, Levenson M, Martinez M, Johnson L, Hibshman J, et al.
Genetics
. 2021 Mar;
217(3).
PMID: 33677541
The auxin-inducible degron (AID) system has emerged as a powerful tool to conditionally deplete proteins in a range of organisms and cell types. Here, we describe a toolkit to augment...
6.
Cabreiro F, Ackerman D, Doonan R, Araiz C, Back P, Papp D, et al.
Free Radic Biol Med
. 2011 Aug;
51(8):1575-82.
PMID: 21839827
The superoxide free radical (O(2)(•-)) has been viewed as a likely major contributor to aging. If this is correct, then superoxide dismutase (SOD), which removes O(2)(•-), should contribute to longevity...
7.
Schuster E, McElwee J, Tullet J, Doonan R, Matthijssens F, Reece-Hoyes J, et al.
Mol Syst Biol
. 2010 Aug;
6:399.
PMID: 20706209
Insulin/IGF-1 signaling controls metabolism, stress resistance and aging in Caenorhabditis elegans by regulating the activity of the DAF-16/FoxO transcription factor (TF). However, the function of DAF-16 and the topology of...
8.
Gems D, Doonan R
Cell Cycle
. 2009 May;
8(11):1681-7.
PMID: 19411855
The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work...
9.
Doonan R, McElwee J, Matthijssens F, Walker G, Houthoofd K, Back P, et al.
Genes Dev
. 2008 Dec;
22(23):3236-41.
PMID: 19056880
The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested...
10.
Doonan R, Hatzold J, Raut S, Conradt B, Alfonso A
Mech Dev
. 2008 Jul;
125(9-10):883-93.
PMID: 18586090
Basic helix-loop-helix (bHLH) proteins of the Achaete/Scute (Ac/Sc) family are required for neurogenesis in both Drosophila and vertebrates. These transcription factors are commonly referred to as 'proneural' factors, as they...