Ruth Goldschmidt
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Explore the profile of Ruth Goldschmidt including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
357
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Recent Articles
1.
Brekelmans J, Dickman M, Verma S, Arba-Mosquera S, Goldschmidt R, Goz A, et al.
Acta Ophthalmol
. 2021 Sep;
100(4):422-430.
PMID: 34533277
Purpose: To determine corneal cross-linking (CXL) efficacy and chromophore penetration after excimer laser-assisted patterned de-epithelialization. Methods: Two-hundred-twenty porcine eyes were de-epithelialized ex vivo, either fully (mechanical; n = 88) or...
2.
Ramot Y, Stone D, Goldschmidt R, Nyska A
Toxicol Pathol
. 2020 Sep;
48(7):909-912.
PMID: 32975499
Intranasal administration of drugs is gaining popularity in medicine, and several animal models have been used to test the safety and efficacy of this delivery route. Nevertheless, the nasal anatomy...
3.
Broekgaarden M, Rizvi I, Bulin A, Petrovic L, Goldschmidt R, Massodi I, et al.
Oncotarget
. 2018 Mar;
9(16):13009-13022.
PMID: 29560127
Effective treatment of advanced metastatic disease remains the primary challenge in the management of inoperable pancreatic cancer. Current therapies such as oxaliplatin (OxPt)-based chemotherapy regimens (FOLFIRINOX) provide modest short-term survival...
4.
Huang H, Mallidi S, Liu J, Chiang C, Mai Z, Goldschmidt R, et al.
Cancer Res
. 2016 Jan;
76(5):1066-77.
PMID: 26719532
The ability of tumor cells to adapt to therapeutic regimens by activating alternative survival and growth pathways remains a major challenge in cancer therapy. Therefore, the most effective treatments will...
5.
Arce P, Khdour O, Goldschmidt R, Armstrong J, Hecht S
ACS Med Chem Lett
. 2014 Jun;
2(8):608-13.
PMID: 24900356
An aza analogue (1) of the experimental neuroprotective drug idebenone has been prepared and evaluated. The compound quenches lipid peroxidation more effectively than α-tocopherol and potently suppresses reactive oxygen species...
6.
Spring B, Abu-Yousif A, Palanisami A, Rizvi I, Zheng X, Mai Z, et al.
Proc Natl Acad Sci U S A
. 2014 Feb;
111(10):E933-42.
PMID: 24572574
Drug-resistant micrometastases that escape standard therapies often go undetected until the emergence of lethal recurrent disease. Here, we show that it is possible to treat microscopic tumors selectively using an...
7.
Fash D, Khdour O, Sahdeo S, Goldschmidt R, Jaruvangsanti J, Dey S, et al.
Bioorg Med Chem
. 2013 Mar;
21(8):2346-2354.
PMID: 23473946
The effect of the alkyl side chain length of coenzyme Q10 on mitochondrial respiratory chain function has been investigated by the use of synthetic ubiquinone derivatives. Three analogues (3, 4...
8.
Goldschmidt R, Arce P, Khdour O, Collin V, Dey S, Jaruvangsanti J, et al.
Bioorg Med Chem
. 2013 Jan;
21(4):969-78.
PMID: 23313093
Two new aza analogues of the neuroprotective agent idebenone have been synthesized and characterized. Their antioxidant activity, and ability to augment ATP levels have been evaluated in several different cell...
9.
Zigdon H, Kogot-Levin A, Park J, Goldschmidt R, Kelly S, Merrill Jr A, et al.
J Biol Chem
. 2013 Jan;
288(7):4947-56.
PMID: 23283968
Ceramide is a key intermediate in the pathway of sphingolipid biosynthesis and is an important intracellular messenger. We recently generated a ceramide synthase 2 (CerS2) null mouse that cannot synthesize...
10.
Arce P, Goldschmidt R, Khdour O, Madathil M, Jaruvangsanti J, Dey S, et al.
Bioorg Med Chem
. 2012 Aug;
20(17):5188-201.
PMID: 22883028
Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the...