Ruth Brack-Werner
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Explore the profile of Ruth Brack-Werner including associated specialties, affiliations and a list of published articles.
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46
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1117
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Recent Articles
1.
Lettl C, Schindele F, Mehdipour A, Steiner T, Ring D, Brack-Werner R, et al.
Cell Chem Biol
. 2023 Apr;
30(5):499-512.e5.
PMID: 37100053
Respiratory complex I is a multicomponent enzyme conserved between eukaryotic cells and many bacteria, which couples oxidation of electron donors and quinone reduction with proton pumping. Here, we report that...
2.
Bauer A, Puglisi M, Nagl D, Schick J, Werner T, Klingl A, et al.
Adv Sci (Weinh)
. 2022 Apr;
9(16):e2104979.
PMID: 35398994
Astrocytes have crucial functions in the central nervous system (CNS) and are major players in many CNS diseases. Research on astrocyte-centered diseases requires efficient and well-characterized gene transfer vectors. Vectors...
3.
Bauer A, Brack-Werner R
Methods Mol Biol
. 2022 Jan;
2407:103-114.
PMID: 34985662
Neurocognitive disorders continue to occur in HIV-infected individuals, despite successful antiretroviral therapy. HIV can persist in the brain for decades, where it infects mainly microglial cells and astrocytes. Brain tissues...
4.
Hofmann S, Mai J, Masser S, Groitl P, Herrmann A, Sternsdorf T, et al.
Adv Sci (Weinh)
. 2020 Apr;
7(8):1902130.
PMID: 32328411
Human adenoviruses (HAdV) are associated with clinical symptoms such as gastroenteritis, keratoconjunctivitis, pneumonia, hepatitis, and encephalitis. In the absence of protective immunity, as in allogeneic bone marrow transplant patients, HAdV...
5.
Herrmann A, Roesner M, Werner T, Hauck S, Koch A, Bauer A, et al.
Sci Rep
. 2020 Jan;
10(1):1326.
PMID: 31992748
Overcoming the global health threat of HIV infection requires continuous pipelines of novel drug candidates. We identified the γ-pyrone polyketides Aureothin/Neoaureothin as potent hits by anti-HIV screening of an extensive...
6.
Mueller C, Kremb S, Gonsior M, Brack-Werner R, Voolstra C, Schmitt-Kopplin P
Sci Rep
. 2020 Jan;
10(1):1319.
PMID: 31992728
Natural products (NP) are a valuable drug resource. However, NP-inspired drug leads are declining, among other reasons due to high re-discovery rates. We developed a conceptual framework using the metabolic...
7.
Gassen N, Niemeyer D, Muth D, Corman V, Martinelli S, Gassen A, et al.
Nat Commun
. 2019 Dec;
10(1):5770.
PMID: 31852899
Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as...
8.
Qian Z, Bruhn T, DAgostino P, Herrmann A, Haslbeck M, Antal N, et al.
J Org Chem
. 2019 Nov;
85(2):664-673.
PMID: 31746205
Genome sequencing and bioinformatic analysis have identified numerous cryptic gene clusters that have the potential to produce novel natural products. Within this work, we identified a cryptic type II PKS...
9.
Sib A, Milzarek T, Herrmann A, Oubraham L, Muller J, Pichlmair A, et al.
Chembiochem
. 2019 Aug;
21(4):492-495.
PMID: 31448469
Sorbicillinoids are fungal polyketides characterized by highly complex and diverse molecular structures, with considerable stereochemical intricacy combined with a high degree of oxygenation. Many sorbicillinoids possess promising biological activities. An...
10.
Overacker R, Banerjee S, Neuhaus G, Milicevic Sephton S, Herrmann A, Strother J, et al.
Bioorg Med Chem
. 2019 Jul;
27(16):3595-3604.
PMID: 31285097
Inspired by bioactive biaryl-containing natural products found in plants and the marine environment, a series of synthetic compounds belonging to the azaBINOL chiral ligand family was evaluated for antiviral activity...