Rupert P Austin
Overview
Explore the profile of Rupert P Austin including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
254
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0
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Recent Articles
1.
Nurzynska K, Austin R, Fischer P, Booth J, Gommer F
J Pharm Sci
. 2016 Oct;
105(11):3464.
PMID: 27742164
No abstract available.
2.
Survival of the Fittest: Time-To-Event Modeling of Crystallization of Amorphous Poorly Soluble Drugs
Nurzynska K, Austin R, Fischer P, Booth J, Gommer F
J Pharm Sci
. 2016 May;
105(6):1858-1866.
PMID: 27238485
The objective of this study was to gain a quantitative understanding of the link between physicochemical properties and long-term and time-censored amorphous stability of poorly water-soluble drugs using parametric time-to-event...
3.
Austin R, Bennion C, Bonnert R, Cheema L, Cook A, Cox R, et al.
Bioorg Med Chem Lett
. 2015 Feb;
25(7):1616-20.
PMID: 25708618
Antagonism of the chemokine receptor CXCR2 has been proposed as a strategy for the treatment of inflammatory diseases such as arthritis, chronic obstructive pulmonary disease and asthma. Earlier series of...
4.
Abraham M, Austin R
Eur J Med Chem
. 2011 Nov;
47(1):202-5.
PMID: 22093757
The effect of neutral molecules on microsomal binding is known through studies by Austin and co-workers, but the effect of ionised species has hitherto not been elucidated. The present work...
5.
Wenlock M, Austin R, Potter T, Barton P
J Lab Autom
. 2011 Jul;
16(4):276-84.
PMID: 21764023
Aqueous solubility is an important physicochemical parameter for any potential drug candidate, and high-throughput kinetic assays are frequently used in drug discovery to give an estimate of a compound's aqueous...
6.
Wenlock M, Barton P, Austin R
J Pharm Biomed Anal
. 2011 Mar;
55(3):385-90.
PMID: 21371844
Traditional methods for the determination of plasma protein binding (PPB), such as equilibrium dialysis and ultrafiltration, normally operate on a timescale ranging from tens of minutes to several hours and...
7.
Wenlock M, Potter T, Barton P, Austin R
J Biomol Screen
. 2011 Feb;
16(3):348-55.
PMID: 21343602
Lipophilicity is an important parameter for any potential drug candidate. Accurate and efficient lipophilicity measurements facilitate the development of high-quality predictive in silico models that support the design of future...
8.
Austin R, Barton P, Davis A, Fessey R, Wenlock M
Pharm Res
. 2005 Sep;
22(10):1649-57.
PMID: 16180122
Purpose: To study the thermodynamics of partitioning of eight ionising dual D2-recepto beta2-adrenoceptor agonists between vesicles of L-alpha-dimyristoylphosphatidylcholine (DMPC) and aqueous buffers. Methods: The thermodynamics of partitioning have been studied...
9.
Austin R, Barton P, Mohmed S, Riley R
Drug Metab Dispos
. 2004 Dec;
33(3):419-25.
PMID: 15616151
The binding of 17 drugs to rat hepatocytes has been determined using equilibrium dialysis in combination with metabolic inhibitors and a kinetic model for the binding and dialysis processes. Metabolic...
10.
Hinchliffe P, Wood J, Davis A, Austin R, Beckett R, Page M
Org Biomol Chem
. 2003 Aug;
1(1):67-80.
PMID: 12929392
N-Acyl-beta-sultams are time dependent irreversible active site directed inhibitors of elastase. The rate of inactivation is first order with respect to beta-sultam concentration and the second order rate constants show...