Ruilan Yan
Overview
Explore the profile of Ruilan Yan including associated specialties, affiliations and a list of published articles.
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20
Citations
719
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Recent Articles
1.
Liu X, Jean-Gilles R, Baginski J, Cai C, Yan R, Zhang L, et al.
Mol Ther Methods Clin Dev
. 2024 Aug;
32(3):101298.
PMID: 39170800
Recombinant adeno-associated virus (rAAV)-based gene therapies are expanding in their application. Despite progress in manufacturing, current analytical methods for product quantification and characterization remain largely unchanged. Although critical for product...
2.
Jezek J, Wang K, Yan R, Di Cristofano A, Cooper K, Strich R
J Cell Sci
. 2019 Jul;
132(16).
PMID: 31331961
The cyclin C-Cdk8 kinase has been identified as both a tumor suppressor and an oncogene depending on the cell type. The genomic locus encoding cyclin C () is often deleted...
3.
Pashos E, Park Y, Wang X, Raghavan A, Yang W, Abbey D, et al.
Cell Stem Cell
. 2017 Apr;
20(4):558-570.e10.
PMID: 28388432
Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of healthy volunteers (n = 91) and used their tissue to...
4.
Bi X, Pashos E, Cuchel M, Lyssenko N, Hernandez M, Picataggi A, et al.
EBioMedicine
. 2017 Mar;
18:139-145.
PMID: 28330813
Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1 deficiency in human hepatocytes is limited. To define the functional...
5.
Zu X, Yan R, Pan J, Zhong L, Cao Y, Ma J, et al.
Mol Carcinog
. 2016 Mar;
56(1):118-129.
PMID: 26969882
Electrophilic carbonyl compounds are highly cytotoxic and genotoxic. Aldo-keto reductase 1B10 (AKR1B10) is an enzyme catalyzing reduction of carbonyl compounds to less toxic alcoholic forms. This study presents novel evidence...
6.
Zhang H, Xue C, Shah R, Bermingham K, Hinkle C, Li W, et al.
Circ Res
. 2015 Apr;
117(1):17-28.
PMID: 25904599
Rationale: An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases. Objective: To perform integrated functional and transcriptome analyses of...
7.
Wang K, Yan R, Cooper K, Strich R
Mol Biol Cell
. 2015 Jan;
26(6):1030-43.
PMID: 25609094
Mitochondria are dynamic organelles that undergo constant fission and fusion cycles. In response to cellular damage, this balance is shifted dramatically toward fission. Cyclin C-Cdk8 kinase regulates transcription of diverse...
8.
Shen Y, Ma J, Yan R, Ling H, Li X, Yang W, et al.
Clin Cancer Res
. 2014 Dec;
21(6):1466-76.
PMID: 25538260
Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but...
9.
Liu Z, Yan R, Al-Salman A, Shen Y, Bu Y, Ma J, et al.
Biochem J
. 2012 Feb;
442(2):273-82.
PMID: 22329800
AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, and plays a critical role in tumour development and progression through promoting lipogenesis and eliminating cytotoxic carbonyls. AKR1B10 is...
10.
Cao D, Ziemba A, McCabe J, Yan R, Wan L, Kim B, et al.
Mol Cancer Ther
. 2011 Sep;
10(12):2330-9.
PMID: 21954436
Abrogation of uridine phosphorylase (UPase) leads to abnormalities in pyrimidine metabolism and host protection against 5-fluorouracil (5-FU) toxicity. We elucidated the effects on the metabolism and antitumor efficacy of 5-FU...