Rudiger Woscholski
Overview
Explore the profile of Rudiger Woscholski including associated specialties, affiliations and a list of published articles.
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46
Citations
851
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Recent Articles
11.
Billcliff P, Noakes C, Mehta Z, Yan G, Mak L, Woscholski R, et al.
Mol Biol Cell
. 2015 Oct;
27(1):90-107.
PMID: 26510499
Mutation of the inositol 5-phosphatase OCRL1 causes Lowe syndrome and Dent-2 disease. Loss of OCRL1 function perturbs several cellular processes, including membrane traffic, but the underlying mechanisms remain poorly defined....
12.
Mak L, Woscholski R
Methods
. 2015 Mar;
77-78:63-8.
PMID: 25747336
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. It's PI(3,4,5)P3 lipid phosphatase activity is an important counteracting mechanism in PI 3-kinase (phosphoinositide...
13.
Furse S, Mak L, Tate E, Templer R, Ces O, Woscholski R, et al.
Org Biomol Chem
. 2014 Dec;
13(7):2001-11.
PMID: 25515724
In this paper evidence is presented that the fatty acid component of an inositide substrate affects the kinetic parameters of the lipid phosphatase Salmonella Outer Protein B (SopB). A succinct...
14.
Murray J, Woscholski R, Spivey A
Chem Commun (Camb)
. 2014 Sep;
50(88):13608-11.
PMID: 25248055
The chemoselective phosphorylation of hydroxyl containing amino acid derivatives and polyols by phosphoryl chlorides catalyzed by 2-aryl-4-(dimethylamino)pyridine-N-oxides is described.
15.
Woscholski R
Biochem Soc Trans
. 2014 Sep;
42(5):1343-8.
PMID: 25233413
Chemical intervention tools have been beneficial to many investigations elucidating signalling networks and interactions. The present review summarizes the current status of chemical tools to probe phosphoinositide metabolism and signalling....
16.
ODonnelly K, Zhao G, Patel P, Butt M, Mak L, Kretschmer S, et al.
Plant Methods
. 2014 Jul;
10:17.
PMID: 24987448
Background: Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is a Calvin Cycle enzyme involved in CO2 assimilation. It is thought to be a major cause of photosynthetic inefficiency, suffering from both a slow catalytic...
17.
Pulido R, Baker S, Barata J, Carracedo A, Cid V, Chin-Sang I, et al.
Sci Signal
. 2014 Jul;
7(332):pe15.
PMID: 24985344
The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN...
18.
Murray J, Spivey A, Woscholski R
J Chem Biol
. 2014 Jan;
6(4):175-84.
PMID: 24432133
Signal transduction cascades in living systems are often controlled via post-translational phosphorylation and dephosphorylation of proteins. These processes are catalyzed in vivo by kinase and phosphatase enzymes, which consequently play...
19.
Whyte G, Vilar R, Woscholski R
J Chem Biol
. 2014 Jan;
6(4):161-74.
PMID: 24432132
Small molecules have long been used for the selective recognition of a wide range of analytes. The ability of these chemical receptors to recognise and bind to specific targets mimics...
20.
Miller D, Booth P, Seddon J, Templer R, Law R, Woscholski R, et al.
J R Soc Interface
. 2013 Aug;
10(87):20130496.
PMID: 23925982
De novo synthetic biological design has the potential to significantly impact upon applications such as energy generation and nanofabrication. Current designs for constructing organisms from component parts are typically limited...