Ruby H P Law
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Explore the profile of Ruby H P Law including associated specialties, affiliations and a list of published articles.
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63
Citations
1984
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Recent Articles
1.
Wiedemeyer S, Wu G, Lang-Henkel H, Whisstock J, Law R, Steinmetzer T
ChemMedChem
. 2024 Aug;
19(23):e202400360.
PMID: 39118493
Two series of macrocyclic inhibitors addressing the S1 pocket and the prime site of the fibrinolytic serine protease plasmin have been developed. In the first series, a P1 tranexamoyl residue...
2.
Cramer D, Yin V, Caval T, Franc V, Yu D, Wu G, et al.
Mol Cell Proteomics
. 2023 Dec;
23(1):100696.
PMID: 38101751
Plasminogen (Plg), the zymogen of plasmin (Plm), is a glycoprotein involved in fibrinolysis and a wide variety of other physiological processes. Plg dysregulation has been implicated in a range of...
3.
Dickeson S, Kumar S, Sun M, Litvak M, He T, Phillips D, et al.
Blood
. 2023 Nov;
143(7):641-650.
PMID: 37992228
Hereditary angioedema (HAE) is associated with episodic kinin-induced swelling of the skin and mucosal membranes. Most patients with HAE have low plasma C1-inhibitor activity, leading to increased generation of the...
4.
Quek A, Cowieson N, Caradoc-Davies T, Conroy P, Whisstock J, Law R
Int J Mol Sci
. 2023 Sep;
24(18).
PMID: 37762561
Plasminogen (Plg) is the inactive form of plasmin (Plm) that exists in two major glycoforms, referred to as glycoforms I and II (GI and GII). In the circulation, Plg assumes...
5.
Jose J, Law R, Leung E, Wai D, Akhlaghi H, Chandrashekaran I, et al.
Eur J Med Chem
. 2023 Sep;
261:115786.
PMID: 37716187
Perforin is a pore-forming protein whose normal function enables cytotoxic T and natural killer (NK) cells to kill virus-infected and transformed cells. Conversely, unwanted perforin activity can also result in...
6.
7.
Wiedemeyer S, Wu G, Pham T, Lang-Henkel H, Perez Urzua B, Whisstock J, et al.
ChemMedChem
. 2023 Jan;
18(6):e202200632.
PMID: 36710259
Two series of macrocyclic plasmin inhibitors with a C-terminal benzylamine group were synthesized. The substitution of the N-terminal phenylsulfonyl group of a previously described inhibitor provided two analogues with sub-nanomolar...
8.
Dickeson S, Kumar S, Sun M, Mohammed B, Phillips D, Whisstock J, et al.
Blood
. 2022 Jan;
139(18):2816-2829.
PMID: 35100351
Patients with hereditary angioedema (HAE) experience episodes of bradykinin (BK)-induced swelling of skin and mucosal membranes. The most common cause is reduced plasma activity of C1 inhibitor, the main regulator...
9.
Shamanaev A, Ivanov I, Sun M, Litvak M, Srivastava P, Mohammed B, et al.
Blood Adv
. 2022 Jan;
6(10):3142-3154.
PMID: 35086137
Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein to the protease plasma kallikrein (PKa). FXII conversion to FXIIa by...
10.
Awad M, Hutton M, Quek A, Klare W, Mileto S, Mackin K, et al.
Gastroenterology
. 2020 Jun;
159(4):1431-1443.e6.
PMID: 32574621
Background & Aims: The protease plasmin is an important wound healing factor, but it is not clear how it affects gastrointestinal infection-mediated damage, such as that resulting from Clostridioides difficile....