Ruben Stepanyan
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Explore the profile of Ruben Stepanyan including associated specialties, affiliations and a list of published articles.
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26
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766
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Recent Articles
1.
Kumar N, Marouf A, Alagramam K, Stepanyan R
Neuroreport
. 2024 Dec;
36(2):93-98.
PMID: 39661536
Noise-induced hearing loss (NIHL) constitutes a significant global health issue for which there is no effective treatment. The loss of cochlear hair cells and associated synaptopathy are common causes of...
2.
Buswinka C, Rosenberg D, Simikyan R, Osgood R, Fernandez K, Nitta H, et al.
Sci Data
. 2024 Apr;
11(1):416.
PMID: 38653806
Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair...
3.
Velez-Ortega A, Stepanyan R, Edelmann S, Torres-Gallego S, Park C, Marinkova D, et al.
Nat Commun
. 2023 Jun;
14(1):3871.
PMID: 37391431
TRPA1 channels are expressed in nociceptive neurons, where they detect noxious stimuli, and in the mammalian cochlea, where their function is unknown. Here we show that TRPA1 activation in the...
4.
Kindig K, Stepanyan R, Kindt K, McDermott Jr B
Curr Biol
. 2023 Mar;
33(7):1295-1307.e3.
PMID: 36905930
In the lateral line system, water motion is detected by neuromast organs, fundamental units that are arrayed on a fish's surface. Each neuromast contains hair cells, specialized mechanoreceptors that convert...
5.
Soler D, Ballesteros A, Sloan A, McCormick T, Stepanyan R
Sci Rep
. 2023 Feb;
13(1):2528.
PMID: 36781873
The mechano-electrical transduction (MET) channel of the inner ear receptor cells, termed hair cells, is a protein complex that enables our senses of hearing and balance. Hair cell MET requires...
6.
Manikandan M, Walker S, Deshmukh A, Perea E, Wang D, Alagramam K, et al.
Sci Rep
. 2021 May;
11(1):9660.
PMID: 33958614
Mitochondrial Ca regulates a wide range of cell processes, including morphogenesis, metabolism, excitotoxicity, and survival. In cochlear hair cells, the activation of mechano-electrical transduction and voltage-gated Ca channels result in...
7.
Zheng Q, Kui L, Xu F, Zheng T, Li B, McCarty M, et al.
Neural Plast
. 2020 Jun;
2020:8889264.
PMID: 32587610
Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about...
8.
Chen Z, Zhu S, Kindig K, Wang S, Chou S, Davis R, et al.
Hum Mol Genet
. 2020 Mar;
29(12):2004-2021.
PMID: 32167554
Perception of sound is initiated by mechanically gated ion channels at the tips of stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations of...
9.
Fogerty J, Stepanyan R, Cianciolo L, Tooke B, Perkins B
Sci Rep
. 2019 Jul;
9(1):10302.
PMID: 31311951
microRNAs are important regulators of gene expression. In the retina, the mir-183/96/182 cluster is of particular interest due to its robust expression and studies in which loss of the cluster...
10.
Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model
Gopal S, Lee Y, Stepanyan R, McDermott Jr B, Alagramam K
Proc Natl Acad Sci U S A
. 2019 May;
116(22):11000-11009.
PMID: 31097578
The pathogenic variant c.144T>G (p.N48K) in the clarin1 gene () results in progressive loss of vision and hearing in Usher syndrome IIIA (USH3A) patients. CLRN1 is predicted to be an...