Kumar N Alagramam
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Explore the profile of Kumar N Alagramam including associated specialties, affiliations and a list of published articles.
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45
Citations
884
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Recent Articles
1.
Kumar N, Marouf A, Alagramam K, Stepanyan R
Neuroreport
. 2024 Dec;
36(2):93-98.
PMID: 39661536
Noise-induced hearing loss (NIHL) constitutes a significant global health issue for which there is no effective treatment. The loss of cochlear hair cells and associated synaptopathy are common causes of...
2.
Patel N, Held I, Trzcinska A, Wasman J, Alagramam K, Oleinick N, et al.
Laryngoscope
. 2024 Aug;
135(1):270-276.
PMID: 39206668
Objective: The silicon phthalocyanine Pc 4 is a photosensitizing agent previously shown to be a promising treatment for cutaneous neoplasms using photodynamic therapy (PDT). Based on prior preclinical studies, we...
3.
Marouf A, Johnson B, Alagramam K
Hum Genet
. 2022 Mar;
141(3-4):759-783.
PMID: 35320418
Usher syndrome (USH) is an autosomal recessive disorder characterized by sensorineural hearing loss, progressive pigmentary retinopathy, and vestibular dysfunction. The degree and onset of hearing loss vary among subtypes I,...
4.
Gilbert B, Zhu S, Salameh A, Sun S, Alagramam K, McDermott Jr B
Front Cell Dev Biol
. 2021 Dec;
9:709442.
PMID: 34917607
To enable hearing, the sensory hair cell contains specialized subcellular structures at its apical region, including the actin-rich cuticular plate and circumferential band. ACF7 (actin crosslinking family protein 7), encoded...
5.
Manikandan M, Walker S, Deshmukh A, Perea E, Wang D, Alagramam K, et al.
Sci Rep
. 2021 May;
11(1):9660.
PMID: 33958614
Mitochondrial Ca regulates a wide range of cell processes, including morphogenesis, metabolism, excitotoxicity, and survival. In cochlear hair cells, the activation of mechano-electrical transduction and voltage-gated Ca channels result in...
6.
Vona B, Mazaheri N, Lin S, Dunbar L, Maroofian R, Azaiez H, et al.
Hum Genet
. 2021 Jan;
140(6):915-931.
PMID: 33496845
Deafness, the most frequent sensory deficit in humans, is extremely heterogeneous with hundreds of genes involved. Clinical and genetic analyses of an extended consanguineous family with pre-lingual, moderate-to-profound autosomal recessive...
7.
Dunbar L, Patni P, Aguilar C, Mburu P, Corns L, Wells H, et al.
EMBO Mol Med
. 2019 Aug;
11(9):e10288.
PMID: 31448880
Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and...
8.
Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model
Gopal S, Lee Y, Stepanyan R, McDermott Jr B, Alagramam K
Proc Natl Acad Sci U S A
. 2019 May;
116(22):11000-11009.
PMID: 31097578
The pathogenic variant c.144T>G (p.N48K) in the clarin1 gene () results in progressive loss of vision and hearing in Usher syndrome IIIA (USH3A) patients. CLRN1 is predicted to be an...
9.
Vargo J, Walker S, Gopal S, Deshmukh A, McDermott Jr B, Alagramam K, et al.
Front Cell Neurosci
. 2018 Jan;
11:393.
PMID: 29311828
Cisplatin and other related platinum antineoplastic drugs are commonly used in the treatment of a variety of cancers in both adults and children but are often associated with severe side...
10.
Mahendrasingam S, Fettiplace R, Alagramam K, Cross E, Furness D
PLoS One
. 2017 Oct;
12(10):e0185285.
PMID: 29069081
Mechanosensory transduction by vertebrate hair cells depends on a protein complex at the tips of shorter stereocilia associated with mechanoelectrical transduction channels activated by tip links in the hair bundle....