Timothy S McClintock
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Explore the profile of Timothy S McClintock including associated specialties, affiliations and a list of published articles.
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714
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Recent Articles
1.
Zhu Z, McClintock T, Bieberich E
Genes Brain Behav
. 2024 Aug;
23(4):e12911.
PMID: 39171374
Neutral sphingomyelinase-2 (nSMase2), gene name sphingomyelin phosphodiesterase-3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid ceramide. The function of nSMase2 in the brain is still controversial. To...
2.
Wang Q, Sengoku T, Titlow W, Strange J, McClintock T
Methods Mol Biol
. 2023 Sep;
2710:111-120.
PMID: 37688728
An increasing diversity of techniques investigating the biology of specific cell types and individual cells have elevated the importance of dissociation of viable cells from living tissues. Here we describe...
3.
Zhu Z, Quadri Z, Crivelli S, Elsherbini A, Zhang L, Tripathi P, et al.
Mol Neurobiol
. 2022 Mar;
59(5):3233-3253.
PMID: 35294731
We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the...
4.
Derby C, McClintock T, Caprio J
Chem Senses
. 2022 Feb;
47.
PMID: 35226060
Our goal in this article is to provide a perspective on how to understand the nature of responses to chemical mixtures. In studying responses to mixtures, researchers often identify "mixture...
5.
Khan N, Alimova Y, Clark S, Vekaria H, Walsh A, Williams H, et al.
J Alzheimers Dis
. 2021 Dec;
85(4):1481-1494.
PMID: 34958025
Background: Alzheimer's disease (AD) is a progressive age-dependent disorder whose risk is affected by genetic factors. Better models for investigating early effects of risk factors such as apolipoprotein E (APOE)...
6.
McClintock T, Khan N, Xie C, Martens J
Chem Senses
. 2020 Oct;
45(9):805-822.
PMID: 33075817
Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over continuously and have a multiciliated dendrite. The extensive changes in gene expression accompanying OSN differentiation in mice are...
7.
McClintock T, Khan N, Alimova Y, Aulisio M, Han D, Breheny P
J Neurosci
. 2020 Aug;
40(37):7043-7053.
PMID: 32801155
The encoding of odors is believed to begin as a combinatorial code consisting of distinct patterns of responses from odorant receptors (ORs), trace-amine associated receptors (TAARs), or both. To determine...
8.
McClintock T, Wang Q, Sengoku T, Titlow W, Breheny P
Chem Senses
. 2020 May;
PMID: 32427281
Natural odors are mixtures of volatile chemicals (odorants). Odors are encoded as responses of distinct subsets of the hundreds of odorant receptors and trace amine-associated receptors expressed monogenically by olfactory...
9.
de March C, Titlow W, Sengoku T, Breheny P, Matsunami H, McClintock T
Mol Cell Neurosci
. 2020 Feb;
104:103469.
PMID: 32061665
The perception of odors relies on combinatorial codes consisting of odorant receptor (OR) response patterns to encode odor identity. Modulation of these patterns by odorant interactions at ORs potentially explains...
10.
Wang Q, Titlow W, McClintock D, Stromberg A, McClintock T
Chem Senses
. 2017 May;
42(8):611-624.
PMID: 28525560
Activity-dependent processes are important to olfactory sensory neurons (OSNs) in several ways, such as cell survival and the specificity of axonal convergence. The identification of activity-dependent mRNAs has contributed to...