Ruben M F Tomas
Overview
Explore the profile of Ruben M F Tomas including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
136
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0
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Recent Articles
1.
Tang Q, Tomas R, Gibson M
Chem Sci
. 2024 Sep;
PMID: 39263661
Non-viral gene delivery with cationic polymers/nanoparticles relies on iterative optimization of the carrier to achieve delivery. Here we demonstrate, instead, that precision engineering of cell surfaces to covalently capture a...
2.
Nagorska A, Tomas R, Tasnim A, Robb N, Gibson M
Biomacromolecules
. 2024 Jul;
25(8):5352-5358.
PMID: 39051654
Plaque assays quantify the amount of active, replicating virus to study and detect infectious diseases by application of samples to monolayers of cultured cells. Due to the time taken in...
3.
Bissoyi A, Gao Y, Tomas R, Kinney N, Whale T, Guo Q, et al.
ACS Appl Mater Interfaces
. 2024 Apr;
PMID: 38671549
Cell-based models, such as organ-on-chips, can replace and inform in vivo (animal) studies for drug discovery, toxicology, and biomedical science, but most cannot be banked "ready to use" as they...
4.
Tomas R, Dallman R, Congdon T, Gibson M
Biomater Sci
. 2023 Oct;
11(23):7639-7654.
PMID: 37840476
Cell culture plays a critical role in biomedical discovery and drug development. Primary hepatocytes and hepatocyte-derived cell lines are especially important cellular models for drug discovery and development. To enable...
5.
Bissoyi A, Tomas R, Gao Y, Guo Q, Gibson M
ACS Appl Mater Interfaces
. 2023 Jan;
15(2):2630-2638.
PMID: 36621888
Spheroids are a powerful tool for basic research and to reduce or replace in vivo (animal) studies but are not routinely banked nor shared. Here, we report the successful cryopreservation...
6.
Tomas R, Bissoyi A, Congdon T, Gibson M
Biomacromolecules
. 2022 Aug;
23(9):3948-3959.
PMID: 35972897
Cell monolayers underpin the discovery and screening of new drugs and allow for fundamental studies of cell biology and disease. However, current cryopreservation technologies do not allow cells to be...
7.
Guy C, Tomas R, Tang Q, Gibson M, Fullam E
Chem Commun (Camb)
. 2022 Aug;
58(67):9361-9364.
PMID: 35917119
Dimeric boronic acids kill () by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development...
8.
Pesenti T, Zhu C, Gonzalez-Martinez N, Tomas R, Gibson M, Nicolas J
ACS Macro Lett
. 2022 Jun;
11(7):889-894.
PMID: 35766585
Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to...
9.
Tomas R, Gibson M
Chem Sci
. 2021 Jun;
12(12):4557-4569.
PMID: 34163721
Synthetic macromolecular chemotherapeutics inspired by host defence peptides can disrupt cell membranes and are emerging as agents for the treatment of cancer and infections. However, their off-target effects remain a...
10.
Murray A, Congdon T, Tomas R, Kilbride P, Gibson M
Biomacromolecules
. 2021 Jun;
23(2):467-477.
PMID: 34097399
From trauma wards to chemotherapy, red blood cells are essential in modern medicine. Current methods to bank red blood cells typically use glycerol (40 wt %) as a cryoprotective agent....