Raymond M Schiffelers
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Explore the profile of Raymond M Schiffelers including associated specialties, affiliations and a list of published articles.
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186
Citations
14198
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Recent Articles
1.
Zhang X, Ye X, Xie Y, Yang Z, Spanos M, Guo Z, et al.
Research (Wash D C)
. 2025 Feb;
8:0609.
PMID: 39949511
The prevention of air pollution-related cardiopulmonary disorders has been largely overlooked despite its important burden. Extracellular vesicles (EVs) have shown great potential as carriers for drug delivery. However, the efficiency...
2.
Elsharkasy O, de Voogt W, Tognoli M, van der Werff L, Gitz-Francois J, Seinen C, et al.
J Biol Chem
. 2025 Feb;
:108305.
PMID: 39947471
Extracellular vesicles (EVs) are cell-derived vesicles secreted by all cell types into the extracellular spaces. EVs comprise a heterogenous population of vesicles that carry bioactive molecules, such as proteins, lipids,...
3.
van Straten D, Bimbo J, Hennink W, Vermonden T, Schiffelers R
Pharmaceutics
. 2025 Jan;
17(1).
PMID: 39861774
Background/objectives: Glioblastoma is the most common and lethal primary brain tumor. Patients often suffer from tumor- and treatment induced vasogenic edema, with devastating neurological consequences. Intracranial edema is effectively treated...
4.
Saber N, Estape Senti M, Schiffelers R
Hum Gene Ther
. 2024 Aug;
35(17-18):617-627.
PMID: 39139067
Lipid nanoparticles (LNPs) are the most clinically advanced drug delivery system for nucleic acid therapeutics, exemplified by the success of the COVID-19 mRNA vaccines. However, their clinical use is currently...
5.
van Straten D, Sork H, van de Schepop L, Frunt R, Ezzat K, Schiffelers R
J Control Release
. 2024 Jul;
373:481-492.
PMID: 39032575
Lipid nanoparticles (LNPs) have successfully entered the clinic for the delivery of mRNA- and siRNA-based therapeutics, most recently as vaccines for COVID-19. Nevertheless, there is a lack of understanding regarding...
6.
Ilahibaks N, Roefs M, Brans M, Blok C, de Jager S, Schiffelers R, et al.
J Extracell Biol
. 2024 Jun;
2(9):e97.
PMID: 38938374
Extracellular vesicles (EVs) are nanoscale particles that facilitate intercellular communication. They are regarded as a promising natural drug delivery system for transporting and delivering bioactive macromolecules to target cells. Recently,...
7.
Al Darwish F, Coolen B, van Kammen C, Alles L, de Vos J, Schiffelers R, et al.
Placenta
. 2024 Apr;
151:19-25.
PMID: 38657321
Introduction: Placental insufficiency may lead to preeclampsia and fetal growth restriction. There is no cure for placental insufficiency, emphasizing the need for monitoring fetal and placenta health. Current monitoring methods...
8.
Francia V, Zhang Y, Cheng M, Schiffelers R, Witzigmann D, Cullis P
Proc Natl Acad Sci U S A
. 2024 Mar;
121(11):e2307803120.
PMID: 38437542
Lipid nanoparticle (LNP) formulations are a proven method for the delivery of nucleic acids for gene therapy as exemplified by the worldwide rollout of LNP-based RNAi therapeutics and mRNA vaccines....
9.
Estape Senti M, Garcia Del Valle L, Schiffelers R
Adv Drug Deliv Rev
. 2024 Feb;
206:115190.
PMID: 38307296
mRNA-based vaccines are emerging as a promising alternative to standard cancer treatments and the conventional vaccines. Moreover, the FDA-approval of three nucleic acid based therapeutics (Onpattro, BNT162b2 and mRNA-1273) has...
10.
Ilahibaks N, Kluiver T, de Jong O, de Jager S, Schiffelers R, Vader P, et al.
J Extracell Vesicles
. 2024 Jan;
13(1):e12389.
PMID: 38191764
The loss-of-function of the proprotein convertase subtilisin-kexin type 9 (Pcsk9) gene has been associated with significant reductions in plasma serum low-density lipoprotein cholesterol (LDL-C) levels. Both CRISPR/Cas9 and CRISPR-based editor-mediated...