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Roxanne M Gilbride

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Articles 25
Citations 1457
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Recent Articles
1.
Wang H, Taher H, Kreklywich C, Schmidt K, Scheef E, Barfield R, et al.
Sci Transl Med . 2025 Mar; 17(789):eadm8961. PMID: 40073152
Congenital cytomegalovirus (cCMV) is the leading infectious cause of neonatal neurological impairment worldwide, but the viral factors enabling vertical spread across the placenta remain undetermined. The pentameric complex (PC), composed...
2.
Otero C, Petkova S, Ebermann M, Taher H, John N, Hoffmann K, et al.
Nat Commun . 2025 Jan; 16(1):1200. PMID: 39885150
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function...
3.
Malouli D, Taher H, Mansouri M, Iyer R, Reed J, Papen C, et al.
Sci Immunol . 2024 Oct; 9(100):eadp5216. PMID: 39392895
Rhesus cytomegalovirus (RhCMV) vectors elicit major histocompatibility complex (MHC)-E-restricted CD8 T cells that stringently control simian immunodeficiency virus (SIV) in rhesus macaques. These responses require deletion of eight RhCMV chemokine-like...
4.
Bimber B, Sunshine J, McElfresh G, Reed J, Pathak R, Bateman K, et al.
Front Immunol . 2024 Aug; 15:1444621. PMID: 39170621
Simian immunodeficiency virus (SIV) vaccines based upon 68-1 Rhesus Cytomegalovirus (RhCMV) vectors show remarkable protection against pathogenic SIVmac239 challenge. Across multiple independent rhesus macaque (RM) challenge studies, nearly 60% of...
5.
Malouli D, Tiwary M, Gilbride R, Morrow D, Hughes C, Selseth A, et al.
Nat Commun . 2024 Jul; 15(1):6007. PMID: 39030218
An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic influenza viruses. Here, to determine if...
6.
Otero C, Petkova S, Ebermann M, Taher H, John N, Hoffmann K, et al.
bioRxiv . 2024 Mar; PMID: 38464092
Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation , but their role in infection and pathogenesis is unknown. To examine the function of vFcγRs in...
7.
Hansen S, Womack J, Perez W, Schmidt K, Marshall E, Iyer R, et al.
JCI Insight . 2023 Feb; 8(6). PMID: 36749635
Rhesus cytomegalovirus-based (RhCMV-based) vaccine vectors induce immune responses that protect ~60% of rhesus macaques (RMs) from SIVmac239 challenge. This efficacy depends on induction of effector memory-based (EM-biased) CD8+ T cells...
8.
Malouli D, Gilbride R, Wu H, Hwang J, Maier N, Hughes C, et al.
Cell Host Microbe . 2022 Aug; 30(9):1207-1218.e7. PMID: 35981532
Strain 68-1 rhesus cytomegalovirus expressing simian immunodeficiency virus (SIV) antigens (RhCMV/SIV) primes MHC-E-restricted CD8+ T cells that control SIV replication in 50%-60% of the vaccinated rhesus macaques. Whether this unconventional...
9.
Smedley J, Bochart R, Fischer M, Funderburgh H, Kelly V, Crank H, et al.
J Med Primatol . 2022 Jul; 51(5):270-277. PMID: 35841132
Background: Identification of lymph nodes (LNs) draining a specific site or in obese macaques can be challenging. Methods: Indocyanine Green (ICG) was administered intradermal (ID), intramuscular, in the oral mucosa,...
10.
Hansen S, Hancock M, Malouli D, Marshall E, Hughes C, Randall K, et al.
Sci Immunol . 2022 Jun; 7(72):eabn9301. PMID: 35714200
The strain 68-1 rhesus cytomegalovirus (RhCMV)-based vaccine for simian immunodeficiency virus (SIV) can stringently protect rhesus macaques (RMs) from SIV challenge by arresting viral replication early in primary infection. This...