Ross A D Bathgate
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Explore the profile of Ross A D Bathgate including associated specialties, affiliations and a list of published articles.
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203
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3126
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Recent Articles
11.
Asadollahi K, Rajput S, de Zhang L, Ang C, Nie S, Williamson N, et al.
Nat Commun
. 2023 Dec;
14(1):8155.
PMID: 38071229
The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states...
12.
Melo M, Wykes A, Connelly A, Bassi J, Cheung S, McDougall S, et al.
Elife
. 2023 Sep;
12.
PMID: 37772793
The pre-Bötzinger complex (preBötC), a key primary generator of the inspiratory breathing rhythm, contains neurons that project directly to facial nucleus (7n) motoneurons to coordinate orofacial and nasofacial activity. To...
13.
Handley T, Praveen P, Tailhades J, Wu H, Bathgate R, Hossain M
Int J Mol Sci
. 2023 Aug;
24(16).
PMID: 37628851
Human relaxin-2 (H2 relaxin) is a peptide hormone with potent vasodilatory and anti-fibrotic effects, which is of interest for the treatment of heart failure and fibrosis. H2 relaxin binds to...
14.
Bathgate R, Praveen P, Sethi A, Furuya W, Dhingra R, Kocan M, et al.
J Am Chem Soc
. 2023 Jul;
145(37):20242-20247.
PMID: 37439676
Peptides and peptidomimetics are attractive drug candidates because of their high target specificity and low-toxicity profiles. Developing peptidomimetics using hydrocarbon (HC)-stapling or other stapling strategies has gained momentum because of...
15.
Bumbak F, Bower J, Zemmer S, Inoue A, Pons M, Paniagua J, et al.
Nat Commun
. 2023 Jun;
14(1):3328.
PMID: 37286565
The neurotensin receptor 1 (NTS) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed...
16.
Dicke A, Albrethsen J, Hoare B, Wyrwoll M, Busch A, Fietz D, et al.
Hum Reprod
. 2023 May;
38(7):1412-1423.
PMID: 37208861
Study Question: What is the impact of variants in the genes INSL3 (Insulin Like 3) and RXFP2 (Relaxin Family Peptide Receptor 2), respectively, on cryptorchidism and male infertility? Summary Answer:...
17.
Hossain M, Praveen P, Noorzi N, Wu H, Harrison I, Handley T, et al.
ACS Pharmacol Transl Sci
. 2023 May;
6(5):842-853.
PMID: 37200817
H2 relaxin is a peptide hormone that exerts its biological actions through the G protein-coupled receptor, RXFP1. The numerous important biological functions of H2 relaxin, including potent renal, vasodilatory, cardioprotective,...
18.
Praveen P, Wang C, Handley T, Wu H, Samuel C, Bathgate R, et al.
Int J Mol Sci
. 2023 Apr;
24(7).
PMID: 37047588
Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin's receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target...
19.
Jin S, Campbell E, Ip C, Layfield S, Bathgate R, Herzog H, et al.
Neurochem Res
. 2023 Apr;
48(8):2490-2501.
PMID: 37017888
The nucleus accumbens shell is a critical node in reward circuitry, encoding environments associated with reward. Long-range inputs from the ventral hippocampus (ventral subiculum) to the nucleus accumbens shell have...
20.
Fernando S, Wang Q, Hay D, Bathgate R, Shepherd P, Lee K
Biosci Rep
. 2023 Mar;
43(4).
PMID: 36947541
RXFP4 is a G protein-coupled receptor (GPCR) in the relaxin family. It has recently been recognised that this receptor and its cognate ligand INSL5 may have a role in the...