Rosa Herbst
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Explore the profile of Rosa Herbst including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
142
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Recent Articles
1.
Bando Y, Klapper M, Herbst R, Sachse A, Stallforth P, Arndt H
Org Lett
. 2025 Mar;
PMID: 40062948
The total synthesis of -derived cyclic lipodepsipeptide anikasin was achieved. Using a depsipeptide building block and balanced protecting groups on the branching d--Thr residue, the synthesis was established semiautomatically on...
2.
Klapper M, Hubner A, Ibrahim A, Wasmuth I, Borry M, Haensch V, et al.
Science
. 2023 May;
380(6645):619-624.
PMID: 37141315
Major advances over the past decade in the field of ancient DNA are providing access to past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this growing paleome...
3.
Gunther M, Reimer C, Herbst R, Kufs J, Rautschek J, Ueberschaar N, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2116122119.
PMID: 36252029
Low-molecular-weight natural products from microbes are indispensable in the development of potent drugs. However, their biological roles within an ecological context often remain elusive. Here, we shed light on natural...
4.
Klapper M, Braga D, Lackner G, Herbst R, Stallforth P
Cell Chem Biol
. 2018 Apr;
25(6):659-665.e9.
PMID: 29606578
Chemical and biochemical analyses of one of the most basic nonribosomal peptide synthetases (NRPS) from a Pseudomonas fluorescens strain revealed its striking plasticity. Determination of the potential substrate scope enabled...
5.
Michalek M, Sonnichsen F, Wechselberger R, Dingley A, Hung C, Kopp A, et al.
Nat Chem Biol
. 2012 Nov;
9(1):37-42.
PMID: 23143413
Human pathogens often produce soluble protein toxins that generate pores inside membranes, resulting in the death of target cells and tissue damage. In pathogenic amoebae, this has been exemplified with...
6.
Muller I, Subert N, Otto H, Herbst R, Ruhling H, Maniak M, et al.
J Biol Chem
. 2005 Jan;
280(11):10435-43.
PMID: 15640146
Lysozymes are bacteria-degrading enzymes and play a major role in the immune defense of animals. In free-living protozoa, lysozyme-like proteins are involved in the digestion of phagocytosed bacteria. Here, we...
7.
Leippe M, Herbst R
J Eukaryot Microbiol
. 2004 Nov;
51(5):516-21.
PMID: 15537085
Pore-forming polypeptides have been purified from several amoeboid protozoans that are well-known human pathogens. Obligate enteric parasites, such as Entamoeba histolytica, and free-living but potentially highly pathogenic species, such as...
8.
Herbst R, Marciano-Cabral F, Leippe M
J Biol Chem
. 2004 Apr;
279(25):25955-8.
PMID: 15075336
The pore-forming polypeptides of Naegleria fowleri, naegleriapores A and B, are processed from separate multipeptide precursor structures. According to their transcripts, each precursor molecule appears to contain additional naegleriapore-like polypeptides,...
9.
Andra J, Herbst R, Leippe M
Dev Comp Immunol
. 2003 Feb;
27(4):291-304.
PMID: 12590963
Antimicrobial peptides are widespread in animal species and their function as defensive molecules may even have appeared before the evolution of metazoa. The amoeboid protozoon Entamoeba histolytica discharge membrane-permeabilizing polypeptides...
10.
Herbst R, Ott C, Jacobs T, Marti T, Marciano-Cabral F, Leippe M
J Biol Chem
. 2002 Apr;
277(25):22353-60.
PMID: 11948186
The free-living amoeboflagellate and potential human pathogen Naegleria fowleri causes the often fatal disease primary amoebic meningoencephalitis. The molecular repertoire responsible for the cytolytic and tissue-destructive activity of this amoeboid...