Ronald J Parchem
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Explore the profile of Ronald J Parchem including associated specialties, affiliations and a list of published articles.
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26
Citations
343
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Recent Articles
11.
Bortoletto A, Graham W, Trout G, Bonito-Oliva A, Kazmi M, Gong J, et al.
Adv Sci (Weinh)
. 2022 Oct;
9(34):e2202342.
PMID: 36257905
Type 2 diabetes mellitus (T2D) is a major public health concern and is characterized by sustained hyperglycemia due to insulin resistance and destruction of insulin-producing β cells. One pathological hallmark...
12.
Gonzalez Corona C, Parchem R
Open Biol
. 2022 Sep;
12(9):220135.
PMID: 36128718
Diabetes is a chronic metabolic disease affecting an increasing number of people. Although diabetes has negative health outcomes for diagnosed individuals, a population at particular risk are pregnant women, as...
13.
Patel I, Parchem R
Birth Defects Res
. 2022 Apr;
114(16):983-1002.
PMID: 35365980
During embryonic development, cells gradually restrict their developmental potential as they exit pluripotency and differentiate into various cell types. The POU transcription factor Oct4 (encoded by Pou5f1) lies at the...
14.
Tao L, Moreno-Smith M, Ibarra-Garcia-Padilla R, Milazzo G, Drolet N, Hernandez B, et al.
Adv Sci (Weinh)
. 2021 Aug;
8(19):e2005047.
PMID: 34365742
Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB patients, but not all patients...
15.
Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers
Keuls R, Parchem R
Front Cell Neurosci
. 2021 May;
15:648570.
PMID: 33935652
Neural crest development involves a series of dynamic, carefully coordinated events that result in human disease when not properly orchestrated. Cranial neural crest cells acquire unique multipotent developmental potential upon...
16.
Keuls R, Kojima K, Lozzi B, Steele J, Chen Q, Gross S, et al.
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33066028
Neural tube closure is a critical early step in central nervous system development that requires precise control of metabolism to ensure proper cellular proliferation and differentiation. Dysregulation of glucose metabolism...
17.
Bonito-Oliva A, Schedin-Weiss S, Younesi S, Tiiman A, Adura C, Paknejad N, et al.
J Cell Mol Med
. 2019 Jan;
23(3):2103-2114.
PMID: 30663210
We engineered and employed a chaperone-like amyloid-binding protein Nucleobindin 1 (NUCB1) to stabilize human islet amyloid polypeptide (hIAPP) protofibrils for use as immunogen in mice. We obtained multiple monoclonal antibody...
18.
Krishnakumar R, Chen A, Pantovich M, Danial M, Parchem R, Labosky P, et al.
Cell Stem Cell
. 2018 Aug;
23(2):306-307.
PMID: 30075131
No abstract available.
19.
Tran N, Kissner M, Subramanyam D, Parchem R, Laird D, Blelloch R
Stem Cells
. 2016 Apr;
34(7):1985-91.
PMID: 27066911
The embryonic stem cell cycle (ESCC) and let-7 families of miRNAs function antagonistically in the switch between mouse embryonic stem cell self-renewal and somatic differentiation. Here, we report that the...
20.
Krishnakumar R, Chen A, Pantovich M, Danial M, Parchem R, Labosky P, et al.
Cell Stem Cell
. 2016 Jan;
18(1):104-17.
PMID: 26748757
Early development is governed by the ability of pluripotent cells to retain the full range of developmental potential and respond accurately to developmental cues. This property is achieved in large...