Rachel A Keuls
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Explore the profile of Rachel A Keuls including associated specialties, affiliations and a list of published articles.
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6
Citations
37
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Recent Articles
1.
Keuls R, Finnell R, Parchem R
Trends Endocrinol Metab
. 2023 Jul;
34(9):539-553.
PMID: 37468429
Changes in maternal nutrient availability due to diet or disease significantly increase the risk of neural tube defects (NTDs). Because the incidence of metabolic disease continues to rise, it is...
2.
Keuls R, Oh Y, Patel I, Parchem R
Proc Natl Acad Sci U S A
. 2023 Feb;
120(6):e2212578120.
PMID: 36724256
Developmental potential is progressively restricted after germ layer specification during gastrulation. However, cranial neural crest cells challenge this paradigm, as they develop from anterior ectoderm, yet give rise to both...
3.
Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers
Keuls R, Parchem R
Front Cell Neurosci
. 2021 May;
15:648570.
PMID: 33935652
Neural crest development involves a series of dynamic, carefully coordinated events that result in human disease when not properly orchestrated. Cranial neural crest cells acquire unique multipotent developmental potential upon...
4.
Parchem J, Kanasaki K, Lee S, Kanasaki M, Yang J, Xu Y, et al.
JCI Insight
. 2020 Dec;
6(2).
PMID: 33301424
The pathogenesis of preeclampsia and other hypertensive disorders of pregnancy remains poorly defined despite the substantial burden of maternal and neonatal morbidity associated with these conditions. In particular, the role...
5.
Keuls R, Parchem R
J Vis Exp
. 2020 Oct;
(164).
PMID: 33104065
MicroRNAs (miRNAs) are important for the complex regulation of cell fate decisions and developmental timing. In vivo studies of the contribution of miRNAs during early development are technically challenging due...
6.
Keuls R, Kojima K, Lozzi B, Steele J, Chen Q, Gross S, et al.
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33066028
Neural tube closure is a critical early step in central nervous system development that requires precise control of metabolism to ensure proper cellular proliferation and differentiation. Dysregulation of glucose metabolism...