Ronald E Reid
Overview
Explore the profile of Ronald E Reid including associated specialties, affiliations and a list of published articles.
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11
Citations
149
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Recent Articles
1.
Bains O, Szeitz A, Lubieniecka J, Cragg G, Grigliatti T, Riggs K, et al.
J Pharmacol Exp Ther
. 2013 Sep;
347(2):375-87.
PMID: 23995598
The role of metabolism in daunorubicin (DAUN)- and doxorubicin (DOX)-associated toxicity in cancer patients is dependent on whether the parent drugs or major metabolites, doxorubicinol (DOXol) and daunorubicinol (DAUNol), are...
2.
Adomat H, Bains O, Lubieniecka J, Gleave M, Guns E, Grigliatti T, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2012 Jul;
902:84-95.
PMID: 22818945
Androgens are key mediators of prostate development and function, a role that extends to the development of prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. In prostate,...
3.
Bains O, Grigliatti T, Reid R, Riggs K
J Pharmacol Exp Ther
. 2010 Sep;
335(3):533-45.
PMID: 20837989
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This may be caused by altered metabolism by nonsynonymous single-nucleotide polymorphisms (ns-SNPs) in...
4.
Bains O, Karkling M, Lubieniecka J, Grigliatti T, Reid R, Riggs K
J Pharmacol Exp Ther
. 2009 Dec;
332(3):755-63.
PMID: 20007405
Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability exists in their pharmacokinetics. This interpatient variability is attributed in part to altered metabolism by nonsynonymous single-nucleotide...
5.
Takahashi R, Grigliatti T, Reid R, Riggs K
J Pharmacol Exp Ther
. 2009 Mar;
329(3):1032-9.
PMID: 19258517
Aldo-keto reductase (AKR) 1C2 is a human, cytosolic enzyme that has an important role in the deactivation of the potent androgen dihydrotestosterone (DHT). AKR1C2 can regulate the extent and duration...
6.
Bains O, Karkling M, Grigliatti T, Reid R, Riggs K
Drug Metab Dispos
. 2009 Feb;
37(5):1107-14.
PMID: 19204081
Carbonyl reductases (CBRs) are a group of metabolic enzymes belonging to the short-chain dehydrogenase family with NADPH-dependent oxidoreductase activity. These enzymes are known to metabolize the anthracyclines doxorubicin (DOX) and...
7.
Takahashi R, Bains O, Pfeifer T, Grigliatti T, Reid R, Riggs K
Drug Metab Dispos
. 2008 Mar;
36(6):991-4.
PMID: 18322072
The anthracycline drugs are important for the treatment of a number of malignancies; however, their clinical use is associated with dose-dependent severe chronic cardiotoxicity. Although the mechanism for this side...
8.
Bains O, Takahashi R, Pfeifer T, Grigliatti T, Reid R, Riggs K
Drug Metab Dispos
. 2008 Feb;
36(5):904-10.
PMID: 18276838
Aldo-keto reductases (AKRs) are a class of NADPH-dependent oxidoreductases that have been linked to metabolism of the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Although widely used, cardiotoxicity continues to be...
9.
Lakowski T, Lee G, Lelj-Garolla B, Okon M, Reid R, McIntosh L
Biochemistry
. 2007 Jun;
46(29):8525-36.
PMID: 17595060
Calmodulin (CaM) is composed of two EF-hand domains tethered by a flexible linker. Upon Ca2+-binding, a fragment of CaM encompassing EF-hands 2 and 3 (CaM2/3; residues 46-113) folds into a...
10.
Lakowski T, Lee G, Okon M, Reid R, McIntosh L
Protein Sci
. 2007 May;
16(6):1119-32.
PMID: 17473011
Calmodulin (CaM) is an EF-hand protein composed of two calcium (Ca(2+))-binding EF-hand motifs in its N-domain (EF-1 and EF-2) and two in its C-domain (EF-3 and EF-4). In this study,...