Lawrence P McIntosh
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Explore the profile of Lawrence P McIntosh including associated specialties, affiliations and a list of published articles.
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88
Citations
1991
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Recent Articles
1.
Lin C, Chan A, Vermeulen J, Brockerman J, Soni A, Tanner M, et al.
J Biol Chem
. 2021 Mar;
296:100528.
PMID: 33711341
The helical morphology of Campylobacter jejuni, a bacterium involved in host gut colonization and pathogenesis in humans, is determined by the structure of the peptidoglycan (PG) layer. This structure is...
2.
Gerak C, Cho S, Kolesnikov M, Okon M, Murphy M, Sessions R, et al.
J Biol Chem
. 2021 Jan;
296:100284.
PMID: 33450226
ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding. Chromosomal translocations frequently generate constitutively active oncoproteins with the ETV6...
3.
Perez-Borrajero C, Heinkel F, Gsponer J, McIntosh L
Biochemistry
. 2021 Jan;
60(2):104-117.
PMID: 33398994
The eukaryotic transcription factor Pax5 has a DNA-binding Paired domain composed of two independent helical bundle subdomains joined by a flexible linker. Previously, we showed distinct biophysical properties of the...
4.
Gerak C, Zhang S, Balgi A, Sadowski I, Sessions R, McIntosh L, et al.
SLAS Discov
. 2020 Dec;
26(5):698-711.
PMID: 33345679
ETV6 is an ETS family transcriptional repressor for which head-to-tail polymerization of its PNT domain facilitates cooperative binding to DNA by its ETS domain. Chromosomal translocations frequently fuse the ETV6...
5.
Majewski D, Okon M, Heinkel F, Robb C, Vuckovic M, McIntosh L, et al.
Structure
. 2020 Sep;
29(2):125-138.e5.
PMID: 32877645
The type III secretion system (T3SS) is a multi-membrane-spanning protein channel used by Gram-negative pathogenic bacteria to secrete effectors directly into the host cell cytoplasm. In the many species reliant...
6.
Terrado M, Okon M, McIntosh L, Plettner E
Biochemistry
. 2020 Sep;
59(37):3411-3426.
PMID: 32877603
Pheromone-binding proteins (PBPs) are small, water-soluble proteins found in the lymph of pheromone-sensing hairs. PBPs are essential in modulating pheromone partitioning in the lymph and at pheromone receptors of olfactory...
7.
Heinkel F, Abraham L, Ko M, Chao J, Bach H, Hui L, et al.
Proc Natl Acad Sci U S A
. 2019 Aug;
116(33):16326-16331.
PMID: 31366629
Phase separation drives numerous cellular processes, ranging from the formation of membrane-less organelles to the cooperative assembly of signaling proteins. Features such as multivalency and intrinsic disorder that enable condensate...
8.
Perez-Borrajero C, Lin C, Okon M, Scheu K, Graves B, Murphy M, et al.
J Mol Biol
. 2019 Jan;
431(3):593-614.
PMID: 30597162
The eukaryotic transcription factor ETS1 is regulated by an intrinsically disordered serine-rich region (SRR) that transiently associates with the adjacent ETS domain to inhibit DNA binding. In this study, we...
9.
Brockerman J, Okon M, Withers S, McIntosh L
Protein Sci
. 2018 Dec;
28(3):620-632.
PMID: 30537432
T4 phage lysozyme (T4L) is an enzyme that cleaves bacterial cell wall peptidoglycan. Remarkably, the single substitution of the active site Thr26 to a His (T26H) converts T4L from an...
10.
Bergeron J, Brockerman J, Vuckovic M, Deng W, Okon M, Finlay B, et al.
Protein Sci
. 2018 Aug;
27(9):1680-1691.
PMID: 30095200
The pathogenic bacterium Salmonella enterica serovar Typhimurium utilizes two type III secretion systems (T3SS) to inject effector proteins into target cells upon infection. The T3SS secretion apparatus (the injectisome) is...