Ronald C Stuart
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Explore the profile of Ronald C Stuart including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
554
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Recent Articles
1.
Faulkner L, Dowling A, Stuart R, Nillni E, Hill J
Endocrinology
. 2015 Jan;
156(4):1372-85.
PMID: 25590244
Proopiomelanocortin (POMC)-derived peptides like α-melanocyte-stimulating hormone (MSH) substantially improve hepatic insulin sensitivity and regulate energy expenditure. Melanocortinergic agents are also powerful inducers of sexual arousal that are being investigated for...
2.
Mercer A, Stuart R, Attard C, Otero-Corchon V, Nillni E, Low M
Am J Physiol Endocrinol Metab
. 2014 Feb;
306(8):E904-15.
PMID: 24518677
Hypothalamic proopiomelanocortin (POMC) neurons constitute a critical anorexigenic node in the central nervous system (CNS) for maintaining energy balance. These neurons directly affect energy expenditure and feeding behavior by releasing...
3.
Nie Y, Ferrini M, Liu Y, Anghel A, Espinosa E, Stuart R, et al.
Peptides
. 2013 Jul;
47:99-109.
PMID: 23891651
The prohormone convertases, PC1/3 and PC2 are thought to be responsible for the activation of many prohormones through processing including the endogenous opioid peptides. We propose that maintenance of hormonal...
4.
Cakir I, Cyr N, Perello M, Patedakis Litvinov B, Romero A, Stuart R, et al.
J Biol Chem
. 2013 May;
288(24):17675-88.
PMID: 23640886
It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity. Our laboratory demonstrated earlier that in the diet-induced obesity...
5.
Chiappini F, Ramadoss P, Vella K, Cunha L, Ye F, Stuart R, et al.
Mol Cell Endocrinol
. 2012 Sep;
365(1):84-94.
PMID: 23000398
Thyrotropin-releasing hormone (TRH) in the paraventricular nucleus (PVN) of the hypothalamus is regulated by thyroid hormone (TH). cAMP response element binding protein (CREB) has also been postulated to regulate TRH...
6.
Cyr N, Stuart R, Zhu X, Steiner D, Nillni E
Peptides
. 2012 Mar;
35(1):42-8.
PMID: 22421509
Prohormone convertases (PCs) 1 and 2 are the primary endoproteases involved in the post-translational processing of proThyrotropin Releasing Hormone (proTRH) to give rise to TRH and other proposed biologically active...
7.
Perello M, Cakir I, Cyr N, Romero A, Stuart R, Chiappini F, et al.
Am J Physiol Endocrinol Metab
. 2010 Sep;
299(6):E976-89.
PMID: 20858755
The hypothalamic-pituitary-thyroid (HPT) axis is a major contributor in maintaining energy expenditure and body weight, and the adipocyte hormone leptin regulates this axis by increasing TRH levels in the fed...
8.
Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan D, Mostoslavsky R, et al.
Cell Metab
. 2010 Jul;
12(1):78-87.
PMID: 20620997
Feeding on high-calorie (HC) diets induces serious metabolic imbalances, including obesity. Understanding the mechanisms against excessive body weight gain is critical for developing effective antiobesity strategies. Here we show that...
9.
Romero A, Cakir I, Vaslet C, Stuart R, Lansari O, Lucero H, et al.
J Biol Chem
. 2008 Sep;
283(46):31438-48.
PMID: 18779326
The biogenesis of rat thyrotropin releasing hormone (TRH) involves the processing of its precursor (proTRH) into five biologically active TRH peptides and several non-TRH peptides where two of them had...
10.
Perello M, Stuart R, Vaslet C, Nillni E
Endocrinology
. 2007 Jun;
148(10):4952-64.
PMID: 17584968
Different physiological conditions affect the biosynthesis and processing of hypophysiotropic proTRH in the hypothalamic paraventricular nucleus, and consequently the output of TRH. Early studies suggest that norepinephrine (NE) mediates the...