Ron Shah
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Explore the profile of Ron Shah including associated specialties, affiliations and a list of published articles.
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11
Citations
2358
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Recent Articles
1.
Shah R, Poon J, Haidasz E, Pratt D
J Org Chem
. 2021 Apr;
86(9):6538-6550.
PMID: 33900079
Alkylated diphenylamines are among the most efficacious radical-trapping antioxidants (RTAs) for applications at elevated temperatures since they are able to trap multiple radical equivalents due to catalytic cycles involving persistent...
2.
Doll S, Porto Freitas F, Shah R, Aldrovandi M, Costa Da Silva M, Ingold I, et al.
Nature
. 2019 Oct;
575(7784):693-698.
PMID: 31634899
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme...
3.
Shah R, Farmer L, Zilka O, Van Kessel A, Pratt D
Cell Chem Biol
. 2019 Oct;
26(11):1594-1607.e7.
PMID: 31564533
"Antioxidant activity" is an often invoked, but generally poorly characterized, molecular property. Several assays are available to determine antioxidant activity, the most popular of which is based upon the ability...
4.
Shah R, Shchepinov M, Pratt D
ACS Cent Sci
. 2018 Apr;
4(3):387-396.
PMID: 29632885
Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of lipid hydroperoxides: the products of LOX catalysis. To provide...
5.
Griesser M, Shah R, Van Kessel A, Zilka O, Haidasz E, Pratt D
J Am Chem Soc
. 2018 Feb;
140(10):3798-3808.
PMID: 29451786
Sterically-hindered nitroxides such as 2,2,6,6-tetramethylpiperidin- N-oxyl (TEMPO) have long been ascribed antioxidant activity that is thought to underlie their chemopreventive and anti-aging properties. However, the most commonly invoked reactions in...
6.
Shah R, Margison K, Pratt D
ACS Chem Biol
. 2017 Aug;
12(10):2538-2545.
PMID: 28837769
Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4...
7.
Zilka O, Shah R, Li B, Friedmann Angeli J, Griesser M, Conrad M, et al.
ACS Cent Sci
. 2017 Apr;
3(3):232-243.
PMID: 28386601
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative diseases in which lipid...
8.
Friedmann Angeli J, Shah R, Pratt D, Conrad M
Trends Pharmacol Sci
. 2017 Apr;
38(5):489-498.
PMID: 28363764
The past decade has yielded tremendous insights into how cells die. This has come with our understanding that several distinct forms of cell death are encompassed under the umbrella term...
9.
Shah R, Pratt D
J Org Chem
. 2016 Jul;
81(15):6649-56.
PMID: 27384266
Hydroperoxides and carboxylic acids are key primary products that arise in the autoxidation of hydrocarbons. We have developed a simple approach to rapidly and simultaneously determine both types of products...
10.
Shah R, Haidasz E, Valgimigli L, Pratt D
J Am Chem Soc
. 2015 Feb;
137(7):2440-3.
PMID: 25668303
The reactivities of novel heterocyclic diarylamine radical-trapping antioxidants (RTAs) are profiled in a heavy hydrocarbon at 160 °C, conditions representative of those at which diphenylamine RTAs are used industrially. While...