Ron Kerkhoven
Overview
Explore the profile of Ron Kerkhoven including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
645
Followers
0
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Recent Articles
1.
Hoekstra M, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, et al.
Cancer Cell
. 2024 Jan;
42(1):157-167.e9.
PMID: 38194914
Cells in the tumor microenvironment (TME) influence each other through secretion and sensing of soluble mediators, such as cytokines and chemokines. While signaling of interferon γ (IFNγ) and tumor necrosis...
2.
Gil-Jimenez A, van Dorp J, Contreras-Sanz A, van der Vos K, Vis D, Braaf L, et al.
Eur Urol
. 2023 Mar;
83(6):e165.
PMID: 36907692
No abstract available.
3.
Lei X, Khatri I, de Wit T, de Rink I, Nieuwland M, Kerkhoven R, et al.
Nat Commun
. 2023 Jan;
14(1):217.
PMID: 36639382
Despite their low abundance in the tumor microenvironment (TME), classical type 1 dendritic cells (cDC1) play a pivotal role in anti-cancer immunity, and their abundance positively correlates with patient survival....
4.
Houthuijzen J, de Bruijn R, van der Burg E, Drenth A, Wientjens E, Filipovic T, et al.
Nat Commun
. 2023 Jan;
14(1):183.
PMID: 36635273
Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of virtually all tumors and strongly impact tumor progression. Despite increasing insight into their function and heterogeneity, little is known regarding...
5.
Krimpenfort R, Behr F, Nieuwland M, de Rink I, Kerkhoven R, von Lindern M, et al.
Biomolecules
. 2022 Nov;
12(11).
PMID: 36421719
E-cadherin is a key regulator of epithelial cell-cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia. The...
6.
Gil-Jimenez A, van Dorp J, Contreras-Sanz A, van der Vos K, Vis D, Braaf L, et al.
Eur Urol
. 2022 Aug;
83(4):313-317.
PMID: 35965206
Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in...
7.
Verhagen C, Vossen D, Borgmann K, Hageman F, Grenman R, Verwijs-Janssen M, et al.
Oncotarget
. 2018 May;
9(26):18198-18213.
PMID: 29719599
Mutations in Fanconi Anemia or Homologous Recombination (FA/HR) genes can cause DNA repair defects and could therefore impact cancer treatment response and patient outcome. Their functional impact and clinical relevance...
8.
Dackus G, Ter Hoeve N, Opdam M, Vreuls W, Varga Z, Koop E, et al.
BMJ Open
. 2017 Nov;
7(11):e017842.
PMID: 29138205
Introduction: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young...
9.
Biesma H, Schouten P, Lacle M, Sanders J, Brugman W, Kerkhoven R, et al.
Genes Chromosomes Cancer
. 2015 Sep;
54(12):734-44.
PMID: 26355282
Genomic aberrations can be used to subtype breast cancer. In this study, we investigated DNA copy number (CN) profiles of 69 cases of male breast cancer (MBC) by array comparative...
10.
de Jong M, Ten Hoeve J, Grenman R, Wessels L, Kerkhoven R, Te Riele H, et al.
Clin Cancer Res
. 2015 Aug;
21(24):5630-8.
PMID: 26265694
Purpose: Predominant causes of head and neck cancer recurrence after radiotherapy are rapid repopulation, hypoxia, fraction of cancer stem cells, and intrinsic radioresistance. Currently, intrinsic radioresistance can only be assessed...