Iris de Rink
Overview
Explore the profile of Iris de Rink including associated specialties, affiliations and a list of published articles.
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22
Citations
989
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Recent Articles
1.
Bakker N, Garner H, van Dyk E, Champanhet E, Klaver C, Duijst M, et al.
NPJ Breast Cancer
. 2025 Jan;
11(1):5.
PMID: 39843922
Cancer disrupts intratumoral innate-adaptive immune crosstalk, but how the systemic immune landscape evolves during breast cancer progression remains unclear. We profiled circulating immune cells in stage I-III and stage IV...
2.
Chen M, Mainardi S, Lieftink C, Velds A, de Rink I, Yang C, et al.
Cell Rep Med
. 2024 Mar;
5(3):101471.
PMID: 38508142
Drug-tolerant persisters (DTPs) are a rare subpopulation of cells within a tumor that can survive therapy through nongenetic adaptive mechanisms to develop relapse and repopulate the tumor following drug withdrawal....
3.
Hoekstra M, Slagter M, Urbanus J, Toebes M, Slingerland N, de Rink I, et al.
Cancer Cell
. 2024 Jan;
42(1):157-167.e9.
PMID: 38194914
Cells in the tumor microenvironment (TME) influence each other through secretion and sensing of soluble mediators, such as cytokines and chemokines. While signaling of interferon γ (IFNγ) and tumor necrosis...
4.
Lei X, Khatri I, de Wit T, de Rink I, Nieuwland M, Kerkhoven R, et al.
Nat Commun
. 2023 Jan;
14(1):217.
PMID: 36639382
Despite their low abundance in the tumor microenvironment (TME), classical type 1 dendritic cells (cDC1) play a pivotal role in anti-cancer immunity, and their abundance positively correlates with patient survival....
5.
Houthuijzen J, de Bruijn R, van der Burg E, Drenth A, Wientjens E, Filipovic T, et al.
Nat Commun
. 2023 Jan;
14(1):183.
PMID: 36635273
Cancer-associated fibroblasts (CAFs) are abundantly present in the microenvironment of virtually all tumors and strongly impact tumor progression. Despite increasing insight into their function and heterogeneity, little is known regarding...
6.
Krimpenfort R, Behr F, Nieuwland M, de Rink I, Kerkhoven R, von Lindern M, et al.
Biomolecules
. 2022 Nov;
12(11).
PMID: 36421719
E-cadherin is a key regulator of epithelial cell-cell adhesion, the loss of which accelerates tumor growth and invasion. E-cadherin is also expressed in hematopoietic cells as well as epithelia. The...
7.
Linder S, Hoogstraat M, Stelloo S, Eickhoff N, Schuurman K, de Barros H, et al.
Cancer Discov
. 2022 Jun;
12(9):2074-2097.
PMID: 35754340
Significance: Understanding how prostate cancers adapt to AR-targeted interventions is critical for identifying novel drug targets to improve the clinical management of treatment-resistant disease. Our study revealed an enzalutamide-induced epigenomic...
8.
Lei X, Palomero J, de Rink I, de Wit T, van Baalen M, Xiao Y, et al.
Front Immunol
. 2021 Apr;
12:621665.
PMID: 33815375
Toll-like receptor 5 (TLR5) is the receptor of bacterial Flagellin. Reportedly, TLR5 engagement helps to combat infections, especially at mucosal sites, by evoking responses from epithelial cells and immune cells....
9.
van Eck van der Sluijs J, van Ens D, Thordardottir S, Vodegel D, Hermens I, van der Waart A, et al.
Cancer Immunol Immunother
. 2021 Apr;
70(11):3167-3181.
PMID: 33796917
Allogeneic stem cell transplantation (alloSCT), following induction chemotherapy, can be curative for hemato-oncology patients due to powerful graft-versus-tumor immunity. However, disease recurrence remains the major cause of treatment failure, emphasizing...
10.
Aslam M, Alemdehy M, Kwesi-Maliepaard E, Muhaimin F, Caganova M, Pardieck I, et al.
EMBO Rep
. 2021 Jan;
22(2):e51184.
PMID: 33410591
Differentiation of naïve peripheral B cells into terminally differentiated plasma cells is characterized by epigenetic alterations, yet the epigenetic mechanisms that control B-cell fate remain unclear. Here, we identified a...