Roman Sakowicz
Overview
Explore the profile of Roman Sakowicz including associated specialties, affiliations and a list of published articles.
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41
Citations
1816
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Recent Articles
1.
Li R, Liclican A, Xu Y, Pitts J, Niu C, Zhang J, et al.
Antimicrob Agents Chemother
. 2021 Jun;
65(9):e0060221.
PMID: 34125594
Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized...
2.
Roberts R, Campbell R, Sikakana P, Sadler C, Osier M, Xu Y, et al.
Toxicol Sci
. 2021 Jun;
183(1):105-116.
PMID: 34117767
GS-9695 and GS-9822 are next-generation noncatalytic site integrase inhibitors (NCINIs) with significantly improved potency against human immunodeficiency virus compared with previous drugs such as BI-224436. Development stopped due to vacuolation...
3.
Xu Y, Barauskas O, Kim C, Babusis D, Murakami E, Kornyeyev D, et al.
Antimicrob Agents Chemother
. 2020 Nov;
65(2).
PMID: 33229429
Remdesivir (RDV, GS-5734), the first FDA-approved antiviral for the treatment of COVID-19, is a single diastereomer monophosphoramidate prodrug of an adenosine analogue. It is intracellularly metabolized into the active triphosphate...
4.
Link J, Rhee M, Tse W, Zheng J, Somoza J, Rowe W, et al.
Nature
. 2020 Jul;
584(7822):614-618.
PMID: 32612233
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis. However, some people living with HIV who are heavily...
5.
Liclican A, Serafini L, Xing W, Czerwieniec G, Steiner B, Wang T, et al.
Biochim Biophys Acta Gen Subj
. 2020 Jan;
1864(4):129531.
PMID: 31953125
Background: Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as ibrutinib in the treatment...
6.
Wong M, Samal A, Lee M, Vlach J, Novikov N, Niedziela-Majka A, et al.
J Mol Biol
. 2019 Feb;
431(7):1440-1459.
PMID: 30753871
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca/CaM) through a direct binding...
7.
Barauskas O, Xing W, Aguayo E, Willkom M, Sapre A, Clarke M, et al.
PLoS One
. 2017 Oct;
12(10):e0185998.
PMID: 29020100
Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted...
8.
Xing W, Barauskas O, Kirschberg T, Niedziela-Majka A, Clarke M, Birkus G, et al.
PLoS One
. 2017 Aug;
12(8):e0181969.
PMID: 28809961
Influenza polymerase is a heterotrimer composed of polymerase acidic protein A (PA) and basic proteins 1 (PB1) and 2 (PB2). The endonuclease active site, located in the PA subunit, cleaves...
9.
Appleby T, Greenstein A, Hung M, Liclican A, Velasquez M, Villasenor A, et al.
J Biol Chem
. 2017 Feb;
292(16):6810-6820.
PMID: 28235803
Matrix metalloproteinase 9 (MMP9) is a member of a large family of proteases that are secreted as inactive zymogens. It is a key regulator of the extracellular matrix, involved in...
10.
Feng J, Xu Y, Barauskas O, Perry J, Ahmadyar S, Stepan G, et al.
Antimicrob Agents Chemother
. 2015 Nov;
60(2):806-17.
PMID: 26596942
Toxicity has emerged during the clinical development of many but not all nucleotide inhibitors (NI) of hepatitis C virus (HCV). To better understand the mechanism for adverse events, clinically relevant...