Katherine M Brendza
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Explore the profile of Katherine M Brendza including associated specialties, affiliations and a list of published articles.
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22
Citations
688
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Recent Articles
1.
Gilmore S, Tam D, Cheung T, Snyder C, Farand J, Dick R, et al.
PLoS One
. 2022 Dec;
17(12):e0271145.
PMID: 36477212
Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis...
2.
Liclican A, Serafini L, Xing W, Czerwieniec G, Steiner B, Wang T, et al.
Biochim Biophys Acta Gen Subj
. 2020 Jan;
1864(4):129531.
PMID: 31953125
Background: Bruton's tyrosine kinase (BTK) is a key component of the B-cell receptor (BCR) pathway and a clinically validated target for small molecule inhibitors such as ibrutinib in the treatment...
3.
Niu B, Appleby T, Wang R, Morar M, Voight J, Villasenor A, et al.
Biochemistry
. 2019 Dec;
59(4):541-551.
PMID: 31841311
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of...
4.
Wong M, Samal A, Lee M, Vlach J, Novikov N, Niedziela-Majka A, et al.
J Mol Biol
. 2019 Feb;
431(7):1440-1459.
PMID: 30753871
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca/CaM) through a direct binding...
5.
Samuel D, Xing W, Niedziela-Majka A, Wong J, Hung M, Brendza K, et al.
Antimicrob Agents Chemother
. 2015 Sep;
59(11):7109-12.
PMID: 26324264
GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral...
6.
Kwon H, Xing W, Chan K, Niedziela-Majka A, Brendza K, Kirschberg T, et al.
PLoS One
. 2015 Apr;
10(4):e0122844.
PMID: 25856426
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer...
7.
Hung M, Niedziela-Majka A, Jin D, Wong M, Leavitt S, Brendza K, et al.
PLoS One
. 2013 Mar;
8(3):e58035.
PMID: 23472130
During human immunodeficiency virus type-1 (HIV-1) virion maturation, capsid proteins undergo a major rearrangement to form a conical core that protects the viral nucleoprotein complexes. Mutations in the capsid sequence...
8.
Niedziela-Majka A, Lad L, Chisholm J, Lagpacan L, Schwartz K, Hung M, et al.
J Biomol Screen
. 2012 Jul;
17(8):1050-61.
PMID: 22811478
Apolipoprotein A-I (ApoA-I), a primary protein component of high-density lipoprotein (HDL), plays an important role in cholesterol metabolism mediating the formation of HDL and the efflux of cellular cholesterol from...
9.
Hebner C, Han B, Brendza K, Nash M, Sulfab M, Tian Y, et al.
PLoS One
. 2012 Jun;
7(6):e39163.
PMID: 22720059
Tegobuvir (TGV) is a novel non-nucleoside inhibitor (NNI) of HCV RNA replication with demonstrated antiviral activity in patients with genotype 1 chronic HCV infection. The mechanism of action of TGV...
10.
Djagaeva I, Rose D, Lim A, Venter C, Brendza K, Moua P, et al.
Genetics
. 2012 Jun;
192(1):173-83.
PMID: 22714410
Kinesin-1 is a motor protein that moves stepwise along microtubules by employing dimerized kinesin heavy chain (Khc) subunits that alternate cycles of microtubule binding, conformational change, and ATP hydrolysis. Mutations...