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Roman Jerala

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Articles 200
Citations 3916
Followers 0
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Recent Articles
1.
Rihtar E, Fink T, Lebar T, Lainscek D, Kolenc Z, Polajnar L, et al.
Cell Chem Biol . 2025 Feb; PMID: 39952240
Precise control of biological processes by the application of small molecules can increase the safety and efficiency of therapies. Adverse side effects of small molecule signals and/or immunogenicity of regulatory...
2.
Mirosevic S, Khandelwal S, Amerson E, Parks E, Parks M, Cochran L, et al.
Ther Adv Rare Dis . 2025 Feb; 6:26330040251318355. PMID: 39949392
The CTNNB1 Connect & Cure and CTNNB1 Foundation, alongside Asociación CTNNB1, CTNNB1 Italia, Association CTNNB1 France, and researchers and clinicians globally are dedicated to finding effective treatments and cures for...
3.
Snoj J, Zhou W, Ljubetic A, Jerala R
Curr Opin Biotechnol . 2025 Jan; 92:103256. PMID: 39827499
Recent advances in protein engineering have revolutionized the design of bionanomolecular assemblies for functional therapeutic and biotechnological applications. This review highlights the progress in creating complex protein architectures, encompassing both...
4.
Marolt Presen D, Lainscek D, Kinghorn J, Sebestyen Z, Kuball J, Amini L, et al.
Comput Struct Biotechnol J . 2025 Jan; 27:10-16. PMID: 39760072
The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre...
5.
Orehek S, Ramuta T, Lainscek D, Malensek S, Sala M, Bencina M, et al.
Nat Commun . 2024 Dec; 15(1):10801. PMID: 39737979
Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a...
6.
Vidmar S, Smidlehner T, Aupic J, Strmsek Z, Ljubetic A, Xiao F, et al.
Angew Chem Int Ed Engl . 2024 Dec; :e202422075. PMID: 39666653
Versatile DNA and polypeptide-based structures have been designed based on complementary modules. However, polypeptides can also form higher oligomeric states. We investigated the introduction of tetrameric modules as a substitute...
7.
Lainscek D, Horvat S, Dolinar K, Ivanovski F, Romih R, Pirkmajer S, et al.
Cell Commun Signal . 2024 Nov; 22(1):549. PMID: 39550582
Various signaling pathways are essential for both the innate immune response and the maintenance of cell homeostasis, requiring coordinated interactions among them. In this study, a mutation in the caspase-1...
8.
Mezgec K, Snoj J, Ulcakar L, Ljubetic A, Znidaric M, Skarabot M, et al.
ACS Nano . 2024 Oct; 18(42):28748-28763. PMID: 39392430
Modular protein engineering is a powerful approach for fabricating high-molecular-weight assemblies and biomaterials with nanoscale precision. Herein, we address the challenge of designing an extended nanoscale filamentous architecture inspired by...
9.
Ivanovski F, Mesko M, Lebar T, Rupnik M, Lainscek D, Gradisek M, et al.
Nat Commun . 2024 Aug; 15(1):7369. PMID: 39191796
Remote regulation of cells in deep tissue remains a significant challenge. Low-intensity pulsed ultrasound offers promise for in vivo therapies due to its non-invasive nature and precise control. This study...
10.
Plaper T, Rihtar E, Ramuta T, Forstneric V, Jazbec V, Ivanovski F, et al.
Cell Chem Biol . 2024 Jul; 31(8):1460-1472. PMID: 38971158
Synthetic biology aims to engineer complex biological systems using modular elements, with coiled-coil (CC) dimer-forming modules are emerging as highly useful building blocks in the regulation of protein assemblies and...