Dusko Lainscek
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Explore the profile of Dusko Lainscek including associated specialties, affiliations and a list of published articles.
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38
Citations
461
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Recent Articles
1.
Cavazza A, Molina-Estevez F, Plaza Reyes A, Ronco V, Naseem A, Malensek S, et al.
Mol Ther Nucleic Acids
. 2025 Feb;
36(1):102457.
PMID: 39991472
In the past decade, precise targeting through genome editing has emerged as a promising alternative to traditional therapeutic approaches. Genome editing can be performed using various platforms, where programmable DNA...
2.
Rihtar E, Fink T, Lebar T, Lainscek D, Kolenc Z, Polajnar L, et al.
Cell Chem Biol
. 2025 Feb;
PMID: 39952240
Precise control of biological processes by the application of small molecules can increase the safety and efficiency of therapies. Adverse side effects of small molecule signals and/or immunogenicity of regulatory...
3.
Mirosevic S, Khandelwal S, Amerson E, Parks E, Parks M, Cochran L, et al.
Ther Adv Rare Dis
. 2025 Feb;
6:26330040251318355.
PMID: 39949392
The CTNNB1 Connect & Cure and CTNNB1 Foundation, alongside Asociación CTNNB1, CTNNB1 Italia, Association CTNNB1 France, and researchers and clinicians globally are dedicated to finding effective treatments and cures for...
4.
Mlakar T, Skrbinek M, Fink T, Lainscek D
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39941106
The innate immune system plays an important role in protecting the organism via recognizing the danger signals and pathogens through pattern recognition receptors. By sensing the danger signal and conveying...
5.
Lainscek D, Forstneric V, Mirosevic S
Mamm Genome
. 2025 Jan;
PMID: 39833474
CTNNB1 syndrome is a rare neurodevelopmental disorder, affecting children worldwide with a prevalence of 2.6-3.2 per 100,000 births and often misdiagnosed as cerebral palsy. De novo loss-of-function mutations in the...
6.
Marolt Presen D, Lainscek D, Kinghorn J, Sebestyen Z, Kuball J, Amini L, et al.
Comput Struct Biotechnol J
. 2025 Jan;
27:10-16.
PMID: 39760072
The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment of the Centre...
7.
Orehek S, Ramuta T, Lainscek D, Malensek S, Sala M, Bencina M, et al.
Nat Commun
. 2024 Dec;
15(1):10801.
PMID: 39737979
Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a...
8.
Lainscek D, Horvat S, Dolinar K, Ivanovski F, Romih R, Pirkmajer S, et al.
Cell Commun Signal
. 2024 Nov;
22(1):549.
PMID: 39550582
Various signaling pathways are essential for both the innate immune response and the maintenance of cell homeostasis, requiring coordinated interactions among them. In this study, a mutation in the caspase-1...
9.
Ivanovski F, Mesko M, Lebar T, Rupnik M, Lainscek D, Gradisek M, et al.
Nat Commun
. 2024 Aug;
15(1):7369.
PMID: 39191796
Remote regulation of cells in deep tissue remains a significant challenge. Low-intensity pulsed ultrasound offers promise for in vivo therapies due to its non-invasive nature and precise control. This study...
10.
Mikolic V, Pantovic-Zalig J, Malensek S, Sever M, Lainscek D, Jerala R
Mol Ther Oncol
. 2024 Jun;
32(2):200815.
PMID: 38840781
Chimeric antigen receptor (CAR) T cell therapy has emerged as a powerful therapeutic approach against a range of hematologic malignancies. While the incorporation of CD28 or 4-1BB costimulatory signaling domains...