Iva Hafner-Bratkovic
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Explore the profile of Iva Hafner-Bratkovic including associated specialties, affiliations and a list of published articles.
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41
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1158
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Recent Articles
1.
Orehek S, Ramuta T, Lainscek D, Malensek S, Sala M, Bencina M, et al.
Nat Commun
. 2024 Dec;
15(1):10801.
PMID: 39737979
Inflammasomes are defense complexes that utilize cytokines and immunogenic cell death (ICD) to stimulate the immune system against pathogens. Inspired by their dual action, we present cytokine-armed pyroptosis as a...
2.
Kulma M, Sakanovic A, Bedina-Zavec A, Caserman S, Omersa N, Solinc G, et al.
Biochem Biophys Res Commun
. 2024 May;
716:149954.
PMID: 38704887
Membrane lipids and proteins form dynamic domains crucial for physiological and pathophysiological processes, including viral infection. Many plasma membrane proteins, residing within membrane domains enriched with cholesterol (CHOL) and sphingomyelin...
3.
Miao R, Jiang C, Chang W, Zhang H, An J, Ho F, et al.
Immunity
. 2023 Nov;
56(11):2523-2541.e8.
PMID: 37924812
Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism and functional consequences are largely unknown. Here, we show that the N-terminal pore-forming GSDMD fragment (GSDMD-NT)...
4.
Susjan-Leite P, Hafner-Bratkovic I
Methods Mol Biol
. 2023 Aug;
2696:257-267.
PMID: 37578728
NACHT-, LRR-, and PYD-containing protein 3 (NLRP3) is a member of AAA+ ATPase family that upon activation forms inflammasomes. Several studies demonstrated that ATP binding and hydrolysis are important for...
5.
Polajnar L, Lainscek D, Gaspersic R, Susjan-Leite P, Kovacic U, Butinar M, et al.
Front Bioeng Biotechnol
. 2023 May;
11:1168330.
PMID: 37234478
Growth factors are the key regulators that promote tissue regeneration and healing processes. While the effects of individual growth factors are well documented, a combination of multiple secreted growth factors...
6.
Devant P, Borsic E, Ngwa E, Xiao H, Chouchani E, Thiagarajah J, et al.
Cell Rep
. 2023 Jan;
42(1):112008.
PMID: 36662620
Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may...
7.
Susjan-Leite P, Ramuta T, Borsic E, Orehek S, Hafner-Bratkovic I
Front Immunol
. 2022 Aug;
13:940969.
PMID: 35979366
The pathogenesis of neurodegenerative diseases involves the accumulation of misfolded protein aggregates. These deposits are both directly toxic to neurons, invoking loss of cell connectivity and cell death, and recognized...
8.
Pavlin M, Lojk J, Strojan K, Hafner-Bratkovic I, Jerala R, Leonardi A, et al.
Int J Mol Sci
. 2022 Jun;
23(11).
PMID: 35682872
Alongside physiochemical properties (PCP), it has been suggested that the protein corona of nanoparticles (NPs) plays a crucial role in the response of immune cells to NPs. However, due to...
9.
Roskar S, Hafner-Bratkovic I
Life (Basel)
. 2022 May;
12(5).
PMID: 35629398
Osteoarthritis is age-related and the most common form of arthritis. The main characteristics of the disease are progressive loss of cartilage and secondary synovial inflammation, which finally result in pain,...
10.
Hafner-Bratkovic I
Trends Biochem Sci
. 2022 Apr;
47(8):635-637.
PMID: 35382945
A recent study by Hochheiser et al. describes the cryo-electron microscopy (cryoEM) structure of an autoinhibited nucleotide-binding domain-, leucine-rich repeat (LRR)- and pyrin domain-containing protein 3 (NLRP3) decamer that assembles...