Roland L Dunbrack
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Explore the profile of Roland L Dunbrack including associated specialties, affiliations and a list of published articles.
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26
Citations
1560
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Recent Articles
1.
Dunbrack R, Dunbrack Jr R
bioRxiv
. 2025 Feb;
PMID: 39990437
AlphaFold's metric is used to predict the accuracy of structural predictions of protein-protein interactions (PPIs) and the probability that two proteins interact. Many AF2/AF3 users have experienced the phenomenon that...
2.
Lee H, Gupta K, Wang L, Dunbrack R, Majtan T, Kruger W
Protein Sci
. 2024 Nov;
33(12):e5223.
PMID: 39548832
Cystathionine beta-synthase (CBS) is an evolutionarily conserved enzyme that plays a key role in mammalian sulfur amino acid biochemistry, mutations in which are the cause of classical homocystinuria (HCU), an...
3.
Dolskii A, Alcantara Dos Santos S, Andrake M, Franco-Barraza J, Dunbrack R, Cukierman E
Cytoskeleton (Hoboken)
. 2024 Sep;
82(3):175-185.
PMID: 39239855
Fibroblasts, crucial for maintaining tissue homeostasis, significantly shape the tumor microenvironment (TME). In pancreatic cancer, a highly aggressive malignancy, cancer-associated fibroblast (CAF)/extracellular matrix (ECM) units dominate the TME, influencing tumor...
4.
Mihai A, Lee S, Shinton S, Parker M, Contreras A, Zhang B, et al.
Nat Commun
. 2024 Jun;
15(1):5078.
PMID: 38871720
T cell receptor (TCR) signaling regulates important developmental transitions, partly through induction of the E protein antagonist, Id3. Although normal γδ T cell development depends on Id3, Id3 deficiency produces...
5.
Vendramini-Costa D, Francescone R, Franco-Barraza J, Luong T, Graves M, de Aquino A, et al.
bioRxiv
. 2024 May;
PMID: 38798370
Statement Of Significance: Here we uncovered the pro-tumor roles of the synaptic protein NGL-1 in the tumor microenvironment of pancreatic cancer, defining a new target that simultaneously modulates tumor cell,...
6.
Schweke H, Xu Q, Tauriello G, Pantolini L, Schwede T, Cazals F, et al.
Proteomics
. 2023 Jun;
23(17):e2200323.
PMID: 37365936
Reliably scoring and ranking candidate models of protein complexes and assigning their oligomeric state from the structure of the crystal lattice represent outstanding challenges. A community-wide effort was launched to...
7.
Hernandez L, Montersino A, Niu J, Guo S, Faezov B, Sanders S, et al.
J Biol Chem
. 2023 Jun;
299(8):104965.
PMID: 37356718
Janus Kinase-1 (JAK1) plays key roles during neurodevelopment and following neuronal injury, while activatory JAK1 mutations are linked to leukemia. In mice, Jak1 genetic deletion results in perinatal lethality, suggesting...
8.
Wasserman J, Faezov B, Patel K, Kurimchak A, Palacio S, Fowle H, et al.
bioRxiv
. 2023 Mar;
PMID: 36945596
The Ser/Thr protein phosphatase 2A (PP2A) is a highly conserved collection of heterotrimeric holoenzymes responsible for the dephosphorylation of many regulated phosphoproteins. Substrate recognition and the integration of regulatory cues...
9.
Tang R, Shuldiner E, Kelly M, Murray C, Hebert J, Andrejka L, et al.
Nat Cell Biol
. 2023 Jan;
25(1):159-169.
PMID: 36635501
Oncogenic KRAS mutations occur in approximately 30% of lung adenocarcinoma. Despite several decades of effort, oncogenic KRAS-driven lung cancer remains difficult to treat, and our understanding of the regulators of...
10.
Xu Q, Dunbrack R
Nucleic Acids Res
. 2022 Oct;
51(D1):D466-D478.
PMID: 36300618
Proteins often act through oligomeric interactions with other proteins. X-ray crystallography and cryo-electron microscopy provide detailed information on the structures of biological assemblies, defined as the most likely biologically relevant...