Brennan C McEwan
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Explore the profile of Brennan C McEwan including associated specialties, affiliations and a list of published articles.
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7
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44
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Recent Articles
1.
Kruse T, Garvanska D, Varga J, Garland W, McEwan B, Hein J, et al.
Sci Adv
. 2024 Oct;
10(40):eadp5491.
PMID: 39356758
The PP2A-B55 phosphatase regulates a plethora of signaling pathways throughout eukaryotes. How PP2A-B55 selects its substrates presents a severe knowledge gap. By integrating AlphaFold modeling with comprehensive high-resolution mutational scanning,...
2.
Wasserman J, Faezov B, Patel K, Kurimchak A, Palacio S, Glass D, et al.
Nat Commun
. 2024 Jul;
15(1):5776.
PMID: 38982062
The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved...
3.
Wasserman J, Faezov B, Patel K, Kurimchak A, Palacio S, Fowle H, et al.
bioRxiv
. 2023 Mar;
PMID: 36945596
The Ser/Thr protein phosphatase 2A (PP2A) is a highly conserved collection of heterotrimeric holoenzymes responsible for the dephosphorylation of many regulated phosphoproteins. Substrate recognition and the integration of regulatory cues...
4.
Vit G, Duro J, Rajendraprasad G, Hertz E, Holland L, Weisser M, et al.
EMBO J
. 2022 Jun;
41(14):e110611.
PMID: 35695070
Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The compounds iHAP1...
5.
Kage F, Vicente-Manzanares M, McEwan B, Kettenbach A, Higgs H
Mol Biol Cell
. 2022 Apr;
33(7):ar63.
PMID: 35427150
The formin INF2 polymerizes a calcium-activated cytoplasmic network of actin filaments, which we refer to as calcium-induced actin polymerization (CIA). CIA plays important roles in multiple cellular processes, including mitochondrial...
6.
Fowle H, Zhao Z, Xu Q, Wasserman J, Wang X, Adeyemi M, et al.
Elife
. 2021 Oct;
10.
PMID: 34661528
Protein phosphorylation is a reversible post-translation modification essential in cell signaling. This study addresses a long-standing question as to how the most abundant serine/threonine protein phosphatase 2 (PP2A) holoenzyme, PP2A/B55α,...
7.
Swartz S, Nguyen H, McEwan B, Adamo M, Cheeseman I, Kettenbach A
Elife
. 2021 Aug;
10.
PMID: 34342579
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed...