Dennis E Discher
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Explore the profile of Dennis E Discher including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Anlas A, Sprenger M, Wang M, Ontko N, Phan S, Discher D
bioRxiv
. 2025 Feb;
PMID: 39975263
Solid tumors often have an abundance of collagen-I that stiffens the tissue, and they are invariably driven by mutations that include chromosome losses and gains. These observations are linked here...
2.
Dooling L, Anlas A, Tobin M, Ontko N, Marchena T, Wang M, et al.
bioRxiv
. 2024 Sep;
PMID: 39345601
Macrophages often pervade solid tumors, but their nearest neighbor organization is understudied and potentially enables key functions such as phagocytosis. Here, we observe dynamic macrophage clusters in tumors under conditions...
3.
Hayes B, Wang M, Zhu H, Phan S, Dooling L, Andrechak J, et al.
Elife
. 2024 May;
12.
PMID: 38805560
Solid tumors generally exhibit chromosome copy number variation, which is typically caused by chromosomal instability (CIN) in mitosis. The resulting aneuploidy can drive evolution and associates with poor prognosis in...
4.
Tobin M, Pfeifer C, Zhu P, Hayes B, Wang M, Vashisth M, et al.
Mol Biol Cell
. 2023 Oct;
34(13):br19.
PMID: 37903225
Chromosome numbers often change dynamically in tumors and cultured cells, which complicates therapy as well as understanding genotype-mechanotype relationships. Here we use a live-cell "ChReporter" method to identify cells with...
5.
Hayes B, Zhu H, Andrechak J, Dooling L, Discher D
PNAS Nexus
. 2023 Aug;
2(8):pgad243.
PMID: 37593202
Phagocytic elimination of solid tumors by innate immune cells seems attractive for immunotherapy, particularly because of the possibilities for acquired immunity. However, the approach remains challenging, with blockade of the...
6.
Hayes B, Zhu P, Wang M, Pfeifer C, Xia Y, Phan S, et al.
J Cell Sci
. 2023 Jun;
136(11).
PMID: 37288769
The mechanical environment of a cell can have many effects, but whether it impacts the DNA sequence of a cell has remained unexamined. To investigate this, we developed a live-cell...
7.
Wang M, Phan S, Hayes B, Discher D
Chromosoma
. 2023 May;
133(1):77-92.
PMID: 37256347
Chromosome gains or losses often lead to copy number variations (CNV) and loss of heterozygosity (LOH). Both quantities are low in hematologic "liquid" cancers versus solid tumors in data of...
8.
Ivanovska I, Tobin M, Bai T, Dooling L, Discher D
J Cell Biol
. 2023 May;
222(8).
PMID: 37212777
The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids with...
9.
Dooling L, Andrechak J, Hayes B, Kadu S, Zhang W, Pan R, et al.
Nat Biomed Eng
. 2023 Apr;
7(9):1081-1096.
PMID: 37095318
In solid tumours, the abundance of macrophages is typically associated with a poor prognosis. However, macrophage clusters in tumour-cell nests have been associated with survival in some tumour types. Here,...
10.
Hayes B, Wang M, Zhu H, Phan S, Dooling L, Andrechak J, et al.
bioRxiv
. 2023 Apr;
PMID: 37066426
Chromosomal instability (CIN), a state in which cells undergo mitotic aberrations that generate chromosome copy number variations, generates aneuploidy and is thought to drive cancer evolution. Although associated with poor...