Roelof Ottenhoff
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Explore the profile of Roelof Ottenhoff including associated specialties, affiliations and a list of published articles.
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52
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1428
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Recent Articles
11.
van Rooden E, van Esbroeck A, Baggelaar M, Deng H, Florea B, Marques A, et al.
Front Neurosci
. 2018 Jul;
12:440.
PMID: 30018533
The endocannabinoid system (ECS) is considered to be an endogenous protective system in various neurodegenerative diseases. Niemann-Pick type C (NPC) is a neurodegenerative disease in which the role of the...
12.
van Loon N, Ottenhoff R, Kooijman S, Moeton M, Scheij S, Roscam Abbing R, et al.
Arterioscler Thromb Vasc Biol
. 2018 Jun;
38(8):1785-1795.
PMID: 29903737
Objective- The E3 ubiquitin ligase IDOL (inducible degrader of the LDLR [LDL (low-density lipoprotein) receptor]) is a post-transcriptional regulator of LDLR abundance. Model systems and human genetics support a role...
13.
Gabriel T, Mirzaian M, Hooibrink B, Ottenhoff R, van Roomen C, Aerts J, et al.
PLoS One
. 2017 Jul;
12(7):e0182075.
PMID: 28753653
During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity...
14.
Ben Bdira F, Kallemeijn W, Oussoren S, Scheij S, Bleijlevens B, Florea B, et al.
ACS Chem Biol
. 2017 May;
12(7):1830-1841.
PMID: 28485919
Glucocerebrosidase (GBA) is a lysosomal β-glucosidase that degrades glucosylceramide. Its deficiency results in Gaucher disease (GD). We examined the effects of active site occupancy of GBA on its structural stability....
15.
Cook E, Nelson J, Sorrentino V, Koenis D, Moeton M, Scheij S, et al.
PLoS One
. 2017 Feb;
12(2):e0172721.
PMID: 28231341
Cellular cholesterol metabolism is subject to tight regulation to maintain adequate levels of this central lipid molecule. Herein, the sterol-responsive Liver X Receptors (LXRs) play an important role owing to...
16.
Kallemeijn W, Scheij S, Hoogendoorn S, Witte M, Herrera Moro Chao D, van Roomen C, et al.
PLoS One
. 2017 Feb;
12(2):e0170268.
PMID: 28207759
Deficiency of glucocerebrosidase (GBA) causes Gaucher disease (GD). In the common non-neuronopathic GD type I variant, glucosylceramide accumulates primarily in the lysosomes of visceral macrophages. Supplementing storage cells with lacking...
17.
Marques A, Willems L, Moro D, Florea B, Scheij S, Ottenhoff R, et al.
Chembiochem
. 2016 Dec;
18(4):402-412.
PMID: 28000364
Galactosylceramidase (GALC) is the lysosomal β-galactosidase responsible for the hydrolysis of galactosylceramide. Inherited deficiency in GALC causes Krabbe disease, a devastating neurological disorder characterized by accumulation of galactosylceramide and its...
18.
Kramer G, Wegdam W, Donker-Koopman W, Ottenhoff R, Gaspar P, Verhoek M, et al.
FEBS Open Bio
. 2016 Sep;
6(9):902-13.
PMID: 27642553
Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was...
19.
Tol M, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten S, et al.
Diabetes
. 2016 Jun;
65(9):2591-605.
PMID: 27325287
Aberrant mitochondrial fission plays a pivotal role in the pathogenesis of skeletal muscle insulin resistance. However, fusion-fission dynamics are physiologically regulated by inherent tissue-specific and nutrient-sensitive processes that may have...
20.
Mirzaian M, Wisse P, Ferraz M, Marques A, Gabriel T, van Roomen C, et al.
Clin Chim Acta
. 2016 May;
459:36-44.
PMID: 27221202
We developed a mass spectrometric procedure to quantify sphingosine-1-phosphate (S1P) in biological materials. The use of newly synthesized (13)C5 C18-S1P and commercial C17-S1P as internal standards rendered very similar results...