Roel G J Klein Wolterink
Overview
Explore the profile of Roel G J Klein Wolterink including associated specialties, affiliations and a list of published articles.
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17
Citations
1028
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Recent Articles
1.
Gong Y, Germeraad W, Zhang X, Wu N, Li B, Janssen L, et al.
Mol Ther
. 2024 Jun;
32(8):2711-2727.
PMID: 38943249
Natural killer (NK) cells eliminate infected or cancer cells via their cytotoxic capacity. NKG2A is an inhibitory receptor on NK cells and cancer cells often overexpress its ligand HLA-E to...
2.
Klein Wolterink R, Wu G, Chiu I, Veiga-Fernandes H
Annu Rev Neurosci
. 2022 Apr;
45:339-360.
PMID: 35363534
Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled...
3.
Cardoso F, Klein Wolterink R, Godinho-Silva C, Domingues R, Ribeiro H, da Silva J, et al.
Nature
. 2021 Aug;
597(7876):410-414.
PMID: 34408322
Signals from sympathetic neurons and immune cells regulate adipocytes and thereby contribute to fat tissue biology. Interactions between the nervous and immune systems have recently emerged as important regulators of...
4.
Gong Y, Klein Wolterink R, Gulaia V, Cloosen S, Ehlers F, Wieten L, et al.
Cancers (Basel)
. 2021 Jun;
13(11).
PMID: 34070311
Antibodies are commonly used in cancer immunotherapy because of their high specificity for tumor-associated antigens. The binding of antibodies can have direct effects on tumor cells but also engages natural...
5.
Gong Y, Klein Wolterink R, Wang J, Bos G, Germeraad W
J Hematol Oncol
. 2021 May;
14(1):73.
PMID: 33933160
Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells...
6.
Gong Y, Klein Wolterink R, Janssen I, Groot A, Bos G, Germeraad W
Mol Ther Methods Clin Dev
. 2020 Apr;
17:634-646.
PMID: 32300610
Adoptive natural killer (NK) cell therapy is attaining promising clinical outcomes in recent years, but improvements are needed. Genetic modification of NK cells with a tumor antigen-specific receptor on their...
7.
Klein Wolterink R, Pirzgalska R, Veiga-Fernandes H
Immunity
. 2018 Jul;
49(1):9-11.
PMID: 30021148
Pulmonary neuroimmune networks have emerged as important regulators of lung homeostasis. In a recent issue of Science, Sui et al. show that strategically positioned pulmonary neuroendocrine cells amplify allergic airway...
8.
van Gorkom G, Klein Wolterink R, van Elssen C, Wieten L, Germeraad W, Bos G
Antioxidants (Basel)
. 2018 Mar;
7(3).
PMID: 29534432
Vitamin C or ascorbic acid (AA) is implicated in many biological processes and has been proposed as a supplement for various conditions, including cancer. In this review, we discuss the...
9.
Corneth O, Klein Wolterink R, Hendriks R
Curr Top Microbiol Immunol
. 2015 Sep;
393:67-105.
PMID: 26341110
Since the original identification of Bruton's tyrosine kinase (BTK) as the gene defective in the primary immunodeficiency X-linked agammaglobulinemia (XLA) in 1993, our knowledge on the physiological function of BTK...
10.
Corneth O, Mus A, Asmawidjaja P, Klein Wolterink R, van Nimwegen M, Brem M, et al.
Arthritis Rheumatol
. 2014 Feb;
66(2):340-9.
PMID: 24504806
Objective: Interleukin-17A (IL-17A) signals through the IL-17 receptor (IL-17R) A/C heterodimer. IL-17RA serves as a common receptor subunit for several IL-17 cytokine family members. Lack of IL-17RA signaling may therefore...