Rodrigo A Maillard
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Explore the profile of Rodrigo A Maillard including associated specialties, affiliations and a list of published articles.
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16
Citations
326
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Recent Articles
1.
Dokas S, Taylor D, Good L, Mohanaraj S, Maillard R
Biochemistry
. 2025 Jan;
64(4):801-811.
PMID: 39887300
Understanding the mechanisms of allosteric regulation in response to second messengers is crucial for advancing basic and applied research. This study focuses on the differential allosteric regulation by the ubiquitous...
2.
Kornev A, Weng J, Maillard R, Taylor S
J Mol Biol
. 2023 Dec;
436(2):168395.
PMID: 38097109
In this study, we utilize Protein Residue Networks (PRNs), constructed using Local Spatial Pattern (LSP) alignment, to explore the dynamic behavior of Catabolite Activator Protein (CAP) upon the sequential binding...
3.
Chau A, Bracken K, Bai L, Pham D, Good L, Maillard R
J Biol Chem
. 2023 May;
299(6):104790.
PMID: 37150322
Cyclic-nucleotide binding (CNB) domains are structurally and evolutionarily conserved signaling modules that regulate proteins with diverse folds and functions. Despite a wealth of structural information, the mechanisms by which CNB...
4.
Foroutannejad S, Good L, Lin C, Carter Z, Tadesse M, Lucius A, et al.
Nat Commun
. 2023 Feb;
14(1):1057.
PMID: 36828841
The link between cofactor binding and protein activity is well-established. However, how cofactor interactions modulate folding of large proteins remains unknown. We use optical tweezers, clustering and global fitting to...
5.
Bai L, Malmosi M, Good L, Maillard R
Methods Mol Biol
. 2022 Sep;
2478:483-510.
PMID: 36063332
Signaling proteins are composed of conserved protein interaction domains that serve as allosteric regulatory elements of enzymatic or binding activities. The ubiquitous, structurally conserved cyclic nucleotide binding (CNB) domain is...
6.
Garate F, Dokas S, Lanfranco M, Canavan C, Wang I, Correia J, et al.
J Biol Chem
. 2021 Feb;
296:100480.
PMID: 33640453
Allosteric proteins with multiple subunits and ligand-binding sites are central in regulating biological signals. The cAMP receptor protein from Mycobacterium tuberculosis (CRP) is a global regulator of transcription composed of...
7.
Rivera M, Hao Y, Maillard R, Baez M
Sci Rep
. 2020 Jun;
10(1):9562.
PMID: 32533020
Knots are remarkable topological features in nature. The presence of knots in crystallographic structures of proteins have stimulated considerable research to determine the kinetic and thermodynamic consequences of threading a...
8.
Hao Y, England J, Bellucci L, Paci E, Hodges H, Taylor S, et al.
Nat Commun
. 2019 Sep;
10(1):3984.
PMID: 31484930
Cyclic nucleotide-binding (CNB) domains allosterically regulate the activity of proteins with diverse functions, but the mechanisms that enable the cyclic nucleotide-binding signal to regulate distant domains are not well understood....
9.
England J, Hao Y, Bai L, Glick V, Hodges H, Taylor S, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(32):E7478-E7485.
PMID: 30038016
Protein kinases are dynamic molecular switches that sample multiple conformational states. The regulatory subunit of PKA harbors two cAMP-binding domains [cyclic nucleotide-binding (CNB) domains] that oscillate between inactive and active...
10.
Hao Y, Canavan C, Taylor S, Maillard R
Sci Rep
. 2017 Sep;
7(1):10843.
PMID: 28883488
Optical tweezers has emerged as a powerful tool to study folding, ligand binding, and motor enzymes. The manipulation of proteins with optical tweezers requires attaching molecular handles to the protein...