Roderick R McInnes
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Explore the profile of Roderick R McInnes including associated specialties, affiliations and a list of published articles.
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39
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1758
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Recent Articles
1.
Wyeth M, Pelkey K, Yuan X, Vargish G, Johnston A, Hunt S, et al.
Cell Rep
. 2017 Aug;
20(9):2156-2168.
PMID: 28854365
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited. Because Neto KAR regulation is GluK subunit/Neto isoform...
2.
Sinai L, Ivakine E, Lam E, Deurloo M, Dida J, Zirngibl R, et al.
eNeuro
. 2015 Oct;
2(2).
PMID: 26464974
Src is a nonreceptor protein tyrosine kinase that is expressed widely throughout the central nervous system and is involved in diverse biological functions. Mice homozygous for a spontaneous mutation in...
3.
Mahadevan V, Dargaei Z, Ivakine E, Hartmann A, Ng D, Chevrier J, et al.
Front Cell Neurosci
. 2015 Oct;
9:368.
PMID: 26441539
Neto2 is a transmembrane protein that interacts with the neuron-specific K(+)-Cl(-) cotransporter (KCC2) in the central nervous system (CNS). Efficient KCC2 transport is essential for setting the neuronal Cl(-) gradient,...
4.
Jung C, Atan D, Ng D, Ploder L, Ross S, Klein M, et al.
Proc Natl Acad Sci U S A
. 2015 May;
112(23):E3010-9.
PMID: 26023183
Retinal bipolar (BP) cells mediate the earliest steps in image processing in the visual system, but the genetic pathways that regulate their development and function are incompletely known. We identified...
5.
6.
Jiang K, Wright K, Zhu P, Szego M, Bramall A, Hauswirth W, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(52):E5716-23.
PMID: 25512545
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor...
7.
Mahadevan V, Pressey J, Acton B, Uvarov P, Huang M, Chevrier J, et al.
Cell Rep
. 2014 Jun;
7(6):1762-70.
PMID: 24910435
KCC2 is the neuron-specific K+-Cl(-) cotransporter required for maintaining low intracellular Cl(-), which is essential for fast inhibitory synaptic transmission in the mature CNS. Despite the requirement of KCC2 for...
8.
Wyeth M, Pelkey K, Petralia R, Salter M, McInnes R, McBain C
J Neurosci
. 2014 Jan;
34(2):622-8.
PMID: 24403160
Neto1 and Neto2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function. In the hippocampus, Neto1 enhances the amplitude and prolongs the kinetics of...
9.
Chang I, Bramall A, Baynash A, Rattner A, Rakheja D, Post M, et al.
J Clin Invest
. 2013 May;
123(6):2643-53.
PMID: 23676500
To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered...
10.
Bramall A, Szego M, Pacione L, Chang I, Diez E, DOrleans-Juste P, et al.
PLoS One
. 2013 Mar;
8(2):e58023.
PMID: 23469133
Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR...