Derek van der Kooy
Overview
Explore the profile of Derek van der Kooy including associated specialties, affiliations and a list of published articles.
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144
Citations
5016
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Recent Articles
1.
Jacques K, Coles B, van der Kooy D
Front Cell Dev Biol
. 2025 Mar;
13:1521411.
PMID: 40040790
Previously isolated adult pancreatic precursors called pancreatic multipotent progenitors (which make both pancreatic endocrine and exocrine cell types) originate from the Pancreatic Duodenal Homeobox 1 (PDX1) pancreatic developmental lineage. The...
2.
Belair-Hickey J, Fahmy A, Zhang W, Sajid R, Coles B, Salter M, et al.
Stem Cell Reports
. 2024 Nov;
19(11):1620-1634.
PMID: 39486406
Direct reprogramming involves the conversion of differentiated cell types without returning to an earlier developmental state. Here, we explore how heterogeneity in developmental lineage and maturity of the starting cell...
3.
Rumajogee P, Altamentova S, Li J, Puvanenthirarajah N, Wang J, Asgarihafshejani A, et al.
Int J Mol Sci
. 2024 Sep;
25(17).
PMID: 39273353
Cerebral palsy (CP) is a common neurodevelopmental disorder characterized by pronounced motor dysfunction and resulting in physical disability. Neural precursor cells (NPCs) have shown therapeutic promise in mouse models of...
4.
Maal-Bared G, Yee M, Harding E, Ghebreselassie M, Bergamini M, Choy R, et al.
Eur J Neurosci
. 2024 Apr;
59(12):3422-3444.
PMID: 38679044
Drug dependence is characterized by a switch in motivation wherein a positively reinforcing substance can become negatively reinforcing. Put differently, drug use can transform from a form of pleasure-seeking to...
5.
Mokady D, Charish J, Barretto-Burns P, Grise K, Coles B, Raab S, et al.
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38338800
Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a...
6.
Vargas-Perez H, Minauro-Sanmiguel F, Ting-A-Kee R, Grieder T, Mendez-Diaz M, Prospero-Garcia O, et al.
Neurosci Lett
. 2023 Dec;
820:137597.
PMID: 38110146
According to the opponent-process theory of drug addiction, the intake of an addictive substance initiates two processes: a rapid primary process that results in the drug's rewarding effects, and a...
7.
Yammine S, Burns I, Gosio J, Peluso A, Merritt D, Innes B, et al.
Stem Cells Dev
. 2023 Aug;
32(19-20):606-621.
PMID: 37551982
The mature brain contains an incredible number and diversity of cells that are produced and maintained by heterogeneous pools of neural stem cells (NSCs). Two distinct types of NSCs exist...
8.
Merritt D, MacKay-Clackett I, Almeida S, Tran C, Ansar S, van der Kooy D
Proc Natl Acad Sci U S A
. 2022 Jul;
119(31):e2116957119.
PMID: 35878038
In the mammalian olfactory system, cross-talk between olfactory signals is minimized through physical isolation: individual neurons express one or few olfactory receptors among those encoded in the genome. Physical isolation...
9.
Vargas-Perez H, Grieder T, van der Kooy D
J Psychoactive Drugs
. 2022 Feb;
55(1):62-72.
PMID: 35114904
Aberrant glutamatergic signaling has been closely related to several pathologies of the central nervous system. Glutamatergic activity can induce an increase in neural plasticity mediated by brain-derived neurotrophic factor (BDNF)...
10.
Grieder T, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, et al.
Eur J Neurosci
. 2021 Dec;
55(3):714-724.
PMID: 34963197
Brain-derived neurotrophic factor (BDNF) has been implicated in the transition from a non-dependent motivational state to a drug-dependent and drug-withdrawn motivational state. Chronic nicotine can increase BDNF in the rodent...