Roderick R McInnes
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Explore the profile of Roderick R McInnes including associated specialties, affiliations and a list of published articles.
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39
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1758
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Recent Articles
11.
Ivakine E, Acton B, Mahadevan V, Ormond J, Tang M, Pressey J, et al.
Proc Natl Acad Sci U S A
. 2013 Feb;
110(9):3561-6.
PMID: 23401525
KCC2 is a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) homeostasis and fast inhibitory synaptic transmission in the mature CNS. Despite the critical role of KCC2 in neurons, the...
12.
Tang M, Ivakine E, Mahadevan V, Salter M, McInnes R
PLoS One
. 2012 Dec;
7(12):e51433.
PMID: 23236500
Kainate receptors (KARs) are a class of ionotropic glutamate receptors that are expressed throughout the central nervous system. The function and subcellular localization of KARs are tightly regulated by accessory...
13.
Ross S, McCord A, Jung C, Atan D, Mok S, Hemberg M, et al.
Neuron
. 2012 Jan;
73(2):292-303.
PMID: 22284184
Although transcription factors that repress gene expression play critical roles in nervous system development, their mechanism of action remains to be understood. Here, we report that the Olig-related transcription factor...
14.
Nickerson P, Ronellenfitch K, McEwan J, Kim H, McInnes R, Chow R
PLoS One
. 2011 Nov;
6(10):e27145.
PMID: 22073130
Approaches for manipulating cell type-specific gene expression during development depend on the identification of novel genetic tools. Here, we report the generation of a transgenic mouse line that utilizes Vsx2...
15.
Tang M, Pelkey K, Ng D, Ivakine E, McBain C, Salter M, et al.
J Neurosci
. 2011 Jul;
31(27):10009-18.
PMID: 21734292
Ionotropic glutamate receptors of AMPA, NMDA, and kainate receptor (KAR) subtypes mediate fast excitatory synaptic transmission in the vertebrate CNS. Auxiliary proteins have been identified for AMPA and NMDA receptor...
16.
17.
Vlachantoni D, Bramall A, Murphy M, Taylor R, Shu X, Tulloch B, et al.
Hum Mol Genet
. 2010 Nov;
20(2):322-35.
PMID: 21051333
The role of oxidative stress within photoreceptors (PRs) in inherited photoreceptor degeneration (IPD) is unclear. We investigated this question using four IPD mouse models (Pde6b(rd1/rd1), Pde6b(atrd1/atrd1), Rho(-/-) and Prph2(rds/rds)) and...
18.
Bramall A, Wright A, Jacobson S, McInnes R
Annu Rev Neurosci
. 2010 Jun;
33:441-72.
PMID: 20572772
The association of more than 140 genes with human photoreceptor degenerations, together with studies of animal models of these monogenic diseases, has provided great insight into their pathogenesis. Here we...
19.
Ross S, Mardinly A, McCord A, Zurawski J, Cohen S, Jung C, et al.
Neuron
. 2010 Mar;
65(6):886-98.
PMID: 20346763
Itch is the least well understood of all the somatic senses, and the neural circuits that underlie this sensation are poorly defined. Here we show that the atonal-related transcription factor...
20.
Inoue T, Coles B, Dorval K, Bremner R, Bessho Y, Kageyama R, et al.
Stem Cells
. 2009 Dec;
28(3):489-500.
PMID: 20014120
Retinal stem cells (RSCs) are present in the ciliary margin of the adult human eye and can give rise to all retinal cell types. Here we show that modulation of...