Robert W Nickells
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Explore the profile of Robert W Nickells including associated specialties, affiliations and a list of published articles.
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60
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2180
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Recent Articles
1.
Muench N, Schmitt H, Schlamp C, Su A, Washington K, Nickells R
Transl Vis Sci Technol
. 2024 Nov;
13(11):24.
PMID: 39560629
Purpose: Retinal ganglion cell (RGC) apoptosis and axon regeneration are the principal obstacles challenging the development of successful whole eye transplantation (WET). The purpose of this study was to create...
2.
Oikawa K, Eaton J, Kiland J, Torne O, Mathu V, Nickells R, et al.
Vision Res
. 2024 Nov;
226:108519.
PMID: 39549467
Effective strategies for the neuroprotection and preservation of retinal ganglion cells (RGCs) remain elusive in the management of glaucoma. A spontaneous genetic model of glaucoma has been identified in cats...
3.
Wurl J, Mac Nair C, Dietz J, Shestopalov V, Nickells R
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958624
Glial reactivity is considered a hallmark of damage-induced innate immune responses in the central nervous system. In the visual system, unilateral optic nerve damage elicits dramatic glial reactivity in the...
4.
Maes M, Donahue R, Schlamp C, Marola O, Libby R, Nickells R
Mol Neurodegener
. 2023 Sep;
18(1):67.
PMID: 37752598
Background: Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the...
5.
Marola O, Yablonski S, Shrager P, Nickells R, Libby R
Cell Death Discov
. 2022 Jul;
8(1):331.
PMID: 35869049
No abstract available.
6.
Schmitt H, Fehrman R, Maes M, Yang H, Guo L, Schlamp C, et al.
Invest Ophthalmol Vis Sci
. 2021 Aug;
62(10):14.
PMID: 34398198
Purpose: Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs) after acute optic nerve damage. Consistent with this,...
7.
Donahue R, Fehrman R, Gustafson J, Nickells R
Cell Death Dis
. 2021 Aug;
12(8):781.
PMID: 34376637
Axonal degeneration of retinal ganglion cells (RGCs) causes blindness in glaucoma. Currently, there are no therapies that target axons to prevent them from degenerating. Activation of the BAX protein has...
8.
Muench N, Patel S, Maes M, Donahue R, Ikeda A, Nickells R
Cells
. 2021 Jul;
10(7).
PMID: 34201955
The important roles of mitochondrial function and dysfunction in the process of neurodegeneration are widely acknowledged. Retinal ganglion cells (RGCs) appear to be a highly vulnerable neuronal cell type in...
9.
Grosser J, Fehrman R, Keefe D, Redmon M, Nickells R
BMC Res Notes
. 2021 May;
14(1):198.
PMID: 34022923
Objective: Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features of this peptide,...
10.
Grosser J, Maes M, Nickells R
Apoptosis
. 2021 Jan;
26(1-2):132-145.
PMID: 33426618
Recent advancements in live cell imaging technologies have identified the phenomenon of intracellular propagation of late apoptotic events, such as cytochrome c release and caspase activation. The mechanism, prevalence, and...