Robert W Nickells
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Explore the profile of Robert W Nickells including associated specialties, affiliations and a list of published articles.
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60
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2180
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Recent Articles
11.
Schmitt H, Grosser J, Schlamp C, Nickells R
Exp Eye Res
. 2020 Sep;
200:108244.
PMID: 32971093
High intraocular pressure (IOP) is the most common risk factor associated with glaucoma in humans. While lowering IOP is effective at reducing the rate of retinal ganglion cell (RGC) loss,...
12.
Donahue R, Maes M, Grosser J, Nickells R
Mol Neurobiol
. 2019 Nov;
57(2):1070-1084.
PMID: 31673950
Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to...
13.
Donahue R, Moller-Trane R, Nickells R
Mol Vis
. 2018 Feb;
23:987-1005.
PMID: 29386873
Purpose: Injury to the central nervous system (CNS) leads to transcriptional changes that effect tissue function and govern the process of neurodegeneration. Numerous microarray and RNA-Seq studies have been performed...
14.
Schmitt H, Schlamp C, Nickells R
J Ocul Pharmacol Ther
. 2017 Dec;
34(3):260-273.
PMID: 29211617
Purpose: HDAC3 regulates nuclear atrophy as an early response to axonal injury in retinal ganglion cells (RGCs) following optic nerve crush (ONC). Since conditional knockout of Hdac3 prevents nuclear atrophy...
15.
Nickells R, Schmitt H, Maes M, Schlamp C
Invest Ophthalmol Vis Sci
. 2017 Dec;
58(14):6091-6104.
PMID: 29204649
Purpose: Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful therapeutic for the rescue and regeneration of these cells after optic nerve damage. However, early after damage,...
16.
Maes M, Schlamp C, Nickells R
PLoS One
. 2017 Sep;
12(9):e0184434.
PMID: 28880942
The pro-apoptotic BCL2 gene family member, BAX, plays a pivotal role in the intrinsic apoptotic pathway. Under cellular stress, BAX recruitment to the mitochondria occurs when activated BAX forms dimers,...
17.
Farnoodian M, Wang S, Dietz J, Nickells R, Sorenson C, Sheibani N
Clin Sci (Lond)
. 2017 Jul;
131(15):1763-1780.
PMID: 28679845
Angiogenesis contributes to the pathogenesis of many diseases including exudative age-related macular degeneration (AMD). It is normally kept in check by a tightly balanced production of pro- and anti-angiogenic factors....
18.
Maes M, Schlamp C, Nickells R
Prog Retin Eye Res
. 2017 Jan;
57:1-25.
PMID: 28064040
Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve. For several decades, we have understood that the RGC death process was executed by apoptosis,...
19.
Zhao L, Chen G, Li J, Fu Y, Mavlyutov T, Yao A, et al.
J Control Release
. 2017 Jan;
247:153-166.
PMID: 28063892
Glaucoma is a common blinding disease characterized by loss of retinal ganglion cells (RGCs). To date, there is no clinically available treatment directly targeting RGCs. We aim to develop an...
20.
Mac Nair C, Schlamp C, Montgomery A, Shestopalov V, Nickells R
J Neuroinflammation
. 2016 Apr;
13(1):93.
PMID: 27126275
Background: Retinal ganglion cell (RGC) soma death is a consequence of optic nerve damage, including in optic neuropathies like glaucoma. The activation of the innate immune network in the retina...