Robert W Mahley
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Explore the profile of Robert W Mahley including associated specialties, affiliations and a list of published articles.
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58
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5289
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Recent Articles
1.
Wan M, Liu Y, Li D, Snyder R, Elkin L, Day C, et al.
Nucleic Acids Res
. 2024 Aug;
52(17):10235-10254.
PMID: 39162226
Enhancers, critical regulatory elements within the human genome, are often transcribed into enhancer RNAs. The dysregulation of enhancers leads to diseases collectively termed enhanceropathies. While it is known that enhancers...
2.
Nelson M, Liu P, Agrawal A, Yip O, Blumenfeld J, Traglia M, et al.
Nat Neurosci
. 2023 Nov;
26(12):2104-2121.
PMID: 37957317
Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating pathologies. There is a critical need to...
3.
Cakir Z, Lord S, Zhou Y, Jang G, Polacco B, Eckhardt M, et al.
Mol Cell Proteomics
. 2023 Apr;
22(5):100541.
PMID: 37019383
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer's disease. While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE...
4.
Mahley R
Curr Opin Neurobiol
. 2023 Feb;
79:102684.
PMID: 36753858
Apolipoprotein (apo) E4 sets the stage for neuropathology in Alzheimer's disease (AD) by causing mitochondrial dysfunction and altering mitochondria-associated membranes. Contact and apposition of mitochondrial-endoplasmic reticulum membranes are enhanced in...
5.
Watts J, Grunseich C, Rodriguez Y, Liu Y, Li D, Burdick J, et al.
Nucleic Acids Res
. 2022 Dec;
50(21):12497-12514.
PMID: 36453989
RNA is modified by hundreds of chemical reactions and folds into innumerable shapes. However, the regulatory role of RNA sequence and structure and how dysregulation leads to diseases remain largely...
6.
Orr A, Kim C, Jimenez-Morales D, Newton B, Johnson J, Krogan N, et al.
J Alzheimers Dis
. 2019 Mar;
68(3):991-1011.
PMID: 30883359
Apolipoprotein (apo) E4, the major genetic risk factor for Alzheimer's disease (AD), alters mitochondrial function and metabolism early in AD pathogenesis. When injured or stressed, neurons increase apoE synthesis. Because...
7.
8.
Mahley R
J Mol Med (Berl)
. 2016 Jun;
94(7):739-46.
PMID: 27277824
Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease. It...
9.
Mahley R
Arterioscler Thromb Vasc Biol
. 2016 May;
36(7):1305-15.
PMID: 27174096
ApoE on high-density lipoproteins is primarily responsible for lipid transport and cholesterol homeostasis in the central nervous system (CNS). Normally produced mostly by astrocytes, apoE is also produced under neuropathologic...
10.
Lazaridis I, Patterson N, Mittnik A, Renaud G, Mallick S, Kirsanow K, et al.
Nature
. 2014 Sep;
513(7518):409-13.
PMID: 25230663
We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to...