Aaron T Garrison
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Explore the profile of Aaron T Garrison including associated specialties, affiliations and a list of published articles.
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16
Citations
228
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Recent Articles
1.
Garrison A, Orsi D, Capstick R, Whomble D, Li J, Carter T, et al.
J Med Chem
. 2022 Apr;
65(8):6273-6286.
PMID: 35417155
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M) represents a novel potential target for the treatment of multiple addictive disorders, including opioid use disorder. Through chemical optimization of several functional...
2.
Huigens 3rd R, Brummel B, Tenneti S, Garrison A, Xiao T
Molecules
. 2022 Feb;
27(3).
PMID: 35164376
There are numerous pyrazine and phenazine compounds that demonstrate biological activities relevant to the treatment of disease. In this review, we discuss pyrazine and phenazine agents that have shown potential...
3.
Nguyen T, Poli L, Garrison A
Chem Commun (Camb)
. 2021 Dec;
58(6):827-830.
PMID: 34931645
The use of Pd(OAc) as the catalyst and AgOAc as the oxidant enabled the direct regioselective oxidative C-H/C-H cross-coupling of pyrazolo[1,5-]pyrimidines or pyrazolo[1,5-]pyridines with various five-membered heteroarenes without the need...
4.
Gould R, Gunter B, Bubser M, Matthews R, Teal L, Ragland M, et al.
ACS Chem Neurosci
. 2019 Jul;
10(8):3740-3750.
PMID: 31268669
Opioid use disorder (OUD) is a debilitating neuropsychiatric condition characterized by compulsive opioid use, dependence, and repeated relapse after periods of abstinence. Given the high risk of developing OUD following...
5.
Childress E, Garrison A, Sheldon J, Skaar E, Lindsley C
J Org Chem
. 2019 May;
84(10):6459-6464.
PMID: 31039303
Here, we report the first total synthesis of hinduchelins A-D, a family of nontoxic catechol derivatives from Streptoalloteichus hindustanus, possessing a druglike chemotype and modest iron-chelating ability. A concise synthesis...
6.
Abouelhassan Y, Garrison A, Yang H, Chavez-Riveros A, Burch G, Huigens 3rd R
J Med Chem
. 2019 Apr;
62(17):7618-7642.
PMID: 30951303
Bacteria utilize multiple mechanisms that enable them to gain or acquire resistance to antibiotic therapies during the treatment of infections. In addition, bacteria form biofilms which are surface-attached communities of...
7.
Garrison A, Childress E, Davis D, Lindsley C
J Org Chem
. 2019 Feb;
84(9):5855-5862.
PMID: 30807155
Here we report the first synthesis of a family of novel heterocyclic compounds based on a 5-dihydropyrazolo[3',4':5,6]pyrano[3,4- b]pyridine core. In the course of our drug discovery programs, we had need...
8.
Bender A, Garrison A, Lindsley C
ACS Chem Neurosci
. 2018 Oct;
10(3):1025-1034.
PMID: 30280567
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications....
9.
Garrison A, Abouelhassan Y, Yang H, Yousaf H, Nguyen T, Huigens Iii R
Medchemcomm
. 2018 Aug;
8(4):720-724.
PMID: 30108790
Herein, we disclose the development of a catalyst- and protecting-group-free microwave-enhanced Friedländer synthesis which permits the single-step, convergent assembly of diverse 8-hydroxyquinolines with greatly improved reaction yields over traditional oil...
10.
Garrison A, Abouelhassan Y, Kallifidas D, Tan H, Kim Y, Jin S, et al.
J Med Chem
. 2018 Apr;
61(9):3962-3983.
PMID: 29638121
Bacterial biofilms are surface-attached communities comprised of nonreplicating persister cells housed within a protective extracellular matrix. Biofilms display tolerance toward conventional antibiotics, occur in ∼80% of infections, and lead to...